Avakian E V, Horvath S M, Michael E D, Jacobs S
Clin Pharmacol Ther. 1979 Dec;26(6):777-81. doi: 10.1002/cpt1979266777.
Six male chronic marihuana (MH) users exercised on a bicycle ergometer for 15 min at approximately 50% VO2max under 3 conditions: (1) not smoking (control), (2) after smoking MH containing 7.5 mg (-) delta-9-tetrahydrocannabinol, and (3) after smoking placebo marihuana (PL). The MH was administered double-blind in a counterbalanced repeated-measures design. Heart rates (HRs), arterial blood pressures (BPs), pulmonary ventilation (VE), and oxygen uptake (VO2) were measured during exercise and 15 min recovery. PL had no effect on any of the physiologic variables. Smoking MH had no effect on systolic blood pressure (SBP), diastolic blood pressure (DBP), VE, or VO2, but did induce a marked increase in heart rate which persisted throughout exercise and recovery periods, averaging 34% higher than control values at rest, 18% higher during exercise, and up to 50% higher during recovery. MH smoking increased the product of HR x SBP in all circumstances.
六名男性慢性大麻使用者在三种情况下，以约50%最大摄氧量在自行车测力计上运动15分钟：(1) 不吸烟（对照）；(2) 吸食含7.5毫克(-)δ-9-四氢大麻酚的大麻后；(3) 吸食安慰剂大麻（PL）后。大麻采用双盲、平衡重复测量设计给药。在运动期间和恢复15分钟期间测量心率（HR）、动脉血压（BP）、肺通气量（VE）和摄氧量（VO2）。PL对任何生理变量均无影响。吸食大麻对收缩压（SBP）、舒张压（DBP）、VE或VO2均无影响，但确实导致心率显著增加，在整个运动和恢复期间持续存在，平均比静息对照值高34%，运动期间高18%，恢复期间高达50%。在所有情况下，吸食大麻均增加了HR×SBP的乘积。
