Clark R M
Can Med Assoc J. 1970 Jul 4;103(1):24-8.
A case of granulomatous ileocolitis which also showed features of ulcerative colitis, and in which lesions were believed to be due to inflammation of previously undescribed structures, microdiverticula, was reported previously. Subsequently, sections of the segments of bowel received from 17 cases of regional enteritis and 16 cases of ulcerative colitis were re-examined for the presence of similar microdiverticula and submucosal epithelial elements. The same structures were present in five cases of regional enteritis and in 14 of ulcerative colitis. A granulomatous type of inflammatory response was found in the bowel and lymph nodes in 14 of the 17 cases of regional enteritis, and in none of the cases labelled ulcerative colitis. In spite of this, difficulty was experienced in placing some cases in one or other diagnostic category. This re-emphasizes the possibility that the two conditions may not be etiologically discrete, and that both may be, in fact, related to the presence of microdiverticula. In addition, it may be that colitis cystica profunda is a result of microdiverticulosis in which the submucosal glandular structures attain unusually large proportions.
先前曾报道过一例肉芽肿性回结肠炎，该病例还表现出溃疡性结肠炎的特征，据信其病变是由先前未描述的结构——微憩室的炎症引起的。随后，对取自17例局限性肠炎和16例溃疡性结肠炎患者的肠段切片进行重新检查，以确定是否存在类似的微憩室和黏膜下上皮成分。在5例局限性肠炎和14例溃疡性结肠炎中发现了相同的结构。在17例局限性肠炎患者中，有14例在肠道和淋巴结中发现了肉芽肿性炎症反应，而在标记为溃疡性结肠炎的病例中均未发现。尽管如此，在将一些病例归入这一诊断类别或另一诊断类别时仍遇到困难。这再次强调了这两种疾病在病因上可能并非完全不同，实际上两者都可能与微憩室的存在有关。此外，深部囊性结肠炎可能是微憩室病的结果，其中黏膜下腺结构比例异常增大。
