Dyson J L
J Clin Pathol. 1975 Mar;28(3):189-94. doi: 10.1136/jcp.28.3.189.
Herniation of the glandular epithelium into the submucosa has been observed in 11 out of 27 cases of chronic ulcerative colitis. Glandular herniation was associated with thickening of the muscularis mucosae, with interruption of the muscularis mucosae by lymphoid follicles, and, in five of the 11 cases, with significant crowding of the glands of the mucosa. This study strongly suggests that sustained contraction of the muscularis mucosae, which has been shown by others to be a major feature of chronic ulcerative colitis, is the prime factor in the formation of downgrowths or herniations of the glandular epithelium into the submucosa. Comparison of the cases in which cancer developed with those where there was glandular herniation led to the conclusion that they are independent associations of chronic ulcerative colitis, and that glandular herniation plays no part in the development of dysplasia or cancer.
在27例慢性溃疡性结肠炎病例中，有11例观察到腺上皮疝入黏膜下层。腺性疝与黏膜肌层增厚、黏膜肌层被淋巴滤泡中断有关，在11例中的5例中，还与黏膜腺体显著拥挤有关。这项研究强烈表明，黏膜肌层的持续收缩（其他人已证明这是慢性溃疡性结肠炎的一个主要特征）是腺上皮向下生长或疝入黏膜下层形成的主要因素。对发生癌症的病例与存在腺性疝的病例进行比较后得出结论，它们是慢性溃疡性结肠炎的独立关联，并且腺性疝在发育异常或癌症的发生中不起作用。
