表皮生长因子：高分子量和低分子量形式
Epidermal growth factor: high and low molecular weight forms.
作者信息
Taylor J M, Cohen S, Mitchell W M
出版信息
Proc Natl Acad Sci U S A. 1970 Sep;67(1):164-71. doi: 10.1073/pnas.67.1.164.
Abstract
In crude homogenates of the submaxillary gland of the male mouse, epidermal growth factor (EGF) activity was found almost entirely in a high molecular weight complex (about 74,000 daltons). This high molecular weight form may be reversibly dissociated into EGF and an EGF-binding protein. EGF was found to have a molecular weight of approximately 6400. The EGF-binding protein has a molecular weight of 29,000, and shows arginyl-esterase activity.
摘要
在雄性小鼠颌下腺的粗匀浆中，表皮生长因子（EGF）活性几乎全部存在于一种高分子量复合物（约74,000道尔顿）中。这种高分子量形式可能可逆地解离为EGF和一种EGF结合蛋白。发现EGF的分子量约为6400。EGF结合蛋白的分子量为29,000，并具有精氨酰酯酶活性。
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