保护性疟疾抗体的特性。
Properties of protective malarial antibody.
作者信息
Cohen S, Butcher G A
出版信息
Immunology. 1970 Aug;19(2):369-83.
Abstract
Properties of protective malarial antibody have been studied in cultures of giving average parasite multiplication rates of sixfold in 24 hours. Parasite growth was assessed by incorporation of [H]-leucine into protein. Immune serum has little effect upon the growth of intracellular parasites, but prevents reinvasion of red cells and inhibits the succeeding cycle of parasite development. Protective antibody is present in relatively low titre in immune sera even after long immunization and this may explain certain characteristic features of malarial immunity. Protective antibody in the sera studied is associated with IgG and IgM; its action is not complement dependent, but requires at least two combining sites per molecule. Anti-malarial antibody has several features in common with viral neutralizing antibody.
摘要
在使寄生虫平均繁殖率在24小时内达到六倍的培养物中研究了保护性疟疾抗体的特性。通过将[H] -亮氨酸掺入蛋白质中来评估寄生虫的生长。免疫血清对细胞内寄生虫的生长几乎没有影响，但可防止红细胞再次受到侵袭，并抑制寄生虫发育的后续周期。即使经过长时间免疫，免疫血清中保护性抗体的滴度相对较低，这可能解释了疟疾免疫的某些特征。所研究血清中的保护性抗体与IgG和IgM相关；其作用不依赖补体，但每个分子至少需要两个结合位点。抗疟疾抗体与病毒中和抗体有几个共同特征。
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