[Dynamics of the restorative processes in the liver in chronic poisoning with zolon].

The authors examined the dynamics of the repairing processes in liver of rats after 2 and 4-month intoxication, caused by the phosphor-organic preparation ZOLON. They found that the changes in liver were reversible at this length of intoxication. Glycogen and RNA storage recovered almost to their initial values. Kupffer's cells were hyperplastic and the number of two-nuclear liver cells was increased diffusely in the lobule. The changes in the vascular walls of the periportal areas persisted. The degree of the repairing processes in liver depended on the dose used and the duration of the action. The obtained data could be taken into consideration in preparing hygienic and prophylactic measures for the individuals working with this preparation.