Pogátsa G, Dubecz E
Endokrinologie. 1979;73(3):328-35.
In the dog heart-lung preparation the effects of glucose and mannitol induced hyperosmolality were examined on left ventricular water content, ventricular compliance, cardiac performance, and coronary blood flow. Glucose-induced increase of serum osmolality by more than 20% resulted in a decrease of myocardial water content and an increase of left ventricular diastolic stiffness if insulin was absent, but the changes did not develop if it was present. Insulin failed to prevent the alterations if hyperosmolality was induced with the nonmetabolizable sugar, mannitol. Coronary blood flow increased in each type of experiments. It is concluded that diagnostic and clinical treatment with hyperosmotic solutions of nonmetabolizable agents can account for disturbed left ventricular compliance and decreased cardiac performance, as it may occur in hyperosmolar diabetic coma.
在犬心肺制备模型中，研究了葡萄糖和甘露醇诱导的高渗对左心室含水量、心室顺应性、心脏功能和冠状动脉血流量的影响。如果缺乏胰岛素，葡萄糖诱导血清渗透压升高超过20%会导致心肌含水量降低和左心室舒张硬度增加，但如果存在胰岛素则不会出现这些变化。如果用不可代谢的糖甘露醇诱导高渗，胰岛素无法预防这些改变。在每种实验类型中冠状动脉血流量均增加。得出的结论是，使用不可代谢药物的高渗溶液进行诊断和临床治疗可能会导致左心室顺应性受损和心脏功能下降，这在高渗性糖尿病昏迷中可能会出现。
