Pogátsa G, Koltai M Z, Grósz G
Acta Physiol Acad Sci Hung. 1982;59(4):305-9.
In previous experiments a considerable interstitial oedema developed after myocardial infarction followed by the infusion of 6 mmol/kg/min norepinephrine lasting for 10 min in the 2nd and 48th hours as well as after a 60 min period of ventricular fibrillation during cardiopulmonary bypass. On the other hand myocardial dehydration was induced by hyperosmolality of 320-470 mOsm/l caused by mannitol or glucose after pancreatectomy. A close bilinear correlation was found between the myocardial water content and the increase of ventricular diastolic stiffness. It was further established that the increase of ventricular stiffness is followed by a decrease of the cardiac output index measured during left ventricular afterload. The cardiac output index was lower after myocardial infarction and pancreatectomy than during cardiopulmonary bypass or mannitol-treatment. Of clinical importance is the fact that ventricular performance decreases when myocardial water content exceeds or does not reach the value of 760-790 g water per 1000 g myocardium.
在先前的实验中，心肌梗死后出现了相当程度的间质水肿，在第2小时和第48小时以6 mmol/kg/min的速度输注去甲肾上腺素持续10分钟后，以及在体外循环期间60分钟心室颤动后均出现了这种情况。另一方面，胰腺切除术后，甘露醇或葡萄糖引起的320 - 470 mOsm/l的高渗状态导致心肌脱水。心肌含水量与心室舒张硬度增加之间存在密切的双线性相关性。进一步证实，心室硬度增加后，左心室后负荷期间测得的心输出量指数会降低。心肌梗死和胰腺切除术后的心输出量指数低于体外循环或甘露醇治疗期间。具有临床重要性的事实是，当心肌含水量超过或未达到每1000 g心肌760 - 790 g水的值时，心室功能会下降。
