结核分枝杆菌未选择群体中耐药突变体的概率分布。
Probability distribution of drug-resistant mutants in unselected populations of Mycobacterium tuberculosis.
作者信息
David H L
出版信息
Appl Microbiol. 1970 Nov;20(5):810-4. doi: 10.1128/am.20.5.810-814.1970.
Abstract
The fluctuation test shows that Mycobacterium tuberculosis mutates to resistance to isoniazid, streptomycin, ethambutol and rifampin spontaneously and at random. The average mutation rates for the drugs, in the same order, were calculated to be 2.56 x 10(-8), 2.95 x 10(-8), 10(-7), and 2.25 x 10(-10) mutation per bacterium per generation. The relatively high mutation rate to ethambutol resistance and the low mutation rate to rifampin resistance were confirmed by analyzing the increase in the proportion of mutants with time in a growing population of the tubercle bacilli. The highest proportions of mutants to be expected in unselected populations of the tubercle bacilli were calculated from the results of fluctuation tests.
摘要
波动试验表明，结核分枝杆菌会自发且随机地发生突变，从而对异烟肼、链霉素、乙胺丁醇和利福平产生耐药性。按相同顺序计算，这些药物的平均突变率分别为每代每菌2.56×10⁻⁸、2.95×10⁻⁸、10⁻⁷和2.25×10⁻¹⁰ 次突变。通过分析结核杆菌生长群体中突变体比例随时间的增加，证实了对乙胺丁醇耐药的相对高突变率和对利福平耐药的低突变率。根据波动试验结果计算出未选择的结核杆菌群体中预期的最高突变体比例。
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