Jalleh R D, Kuppusamy I, Soshila R, Aziah A M, Faridza M Y
National Tuberculosis Centre, Kuala Lumpur.
Med J Malaysia. 1993 Jun;48(2):113-6.
Eight hundred and fifty-six strains of Mycobacterium tuberculosis from previously untreated patients with pulmonary tuberculosis from various states in West Malaysia were studied during the period 1984 to 1987. All the strains were tested for in vitro susceptibility to the anti-tuberculosis drugs isoniazid (INH), streptomycin (SM), rifampicin (RMP) and ethambutol (ETB). One hundred and twenty-one of the isolates (14.18%) were resistant to 1 drug while 17 (1.97%) were resistant to 2 drugs. No strain was found to be resistant to more than 2 drugs. The prevalence of primary resistance to INH was 4.20%, SM was 7.59%, RMP was 0.95% and ETB was 1.44%. In 1.86% of isolates, resistance was noted to both INH and SM, while 0.11% were resistant to both RMP and ETB. There was no significant difference in distribution of resistant bacilli between the sexes (p > 0.01).
1984年至1987年期间，对来自马来西亚西部不同州的856株从未接受过治疗的肺结核患者的结核分枝杆菌进行了研究。所有菌株均接受了抗结核药物异烟肼（INH）、链霉素（SM）、利福平（RMP）和乙胺丁醇（ETB）的体外药敏试验。121株分离菌（14.18%）对1种药物耐药，17株（1.97%）对2种药物耐药。未发现对超过2种药物耐药的菌株。对INH的原发性耐药率为4.20%，SM为7.59%，RMP为0.95%，ETB为1.44%。在1.86%的分离株中，发现对INH和SM均耐药，而0.11%对RMP和ETB均耐药。耐药杆菌在性别间的分布无显著差异（p>0.01）。
