通过放射性测量法和传统方法评估链霉素和乙胺丁醇浓度用于结核分枝杆菌药敏试验
Evaluation of streptomycin and ethambutol concentrations for susceptibility testing of Mycobacterium tuberculosis by radiometric and conventional procedures.
作者信息
Woodley C L
出版信息
J Clin Microbiol. 1986 Feb;23(2):385-6. doi: 10.1128/jcm.23.2.385-386.1986.
Abstract
Clinical isolates of Mycobacterium tuberculosis were used to compare various concentrations of streptomycin and ethambutol in the BACTEC 460 (Johnston Laboratories, Inc., Towson, Md.) radiometric method for drug susceptibility testing with those in the conventional method. Streptomycin used at 2.0 micrograms/ml for both methods showed a 0.99 agreement with susceptible strains and a 0.97 agreement with resistant strains. Ethambutol used at 2.5 micrograms/ml for the radiometric method showed 1.00 agreement with both susceptible and resistant strains when compared with ethambutol at 5.0 micrograms/ml for the conventional method.
摘要
结核分枝杆菌临床分离株被用于比较在BACTEC 460（约翰斯顿实验室公司，马里兰州陶森）放射测量法药物敏感性试验中不同浓度的链霉素和乙胺丁醇与传统方法中的情况。两种方法中链霉素均使用2.0微克/毫升，其与敏感菌株的一致性为0.99，与耐药菌株的一致性为0.97。放射测量法中乙胺丁醇使用2.5微克/毫升，与传统方法中5.0微克/毫升的乙胺丁醇相比，其与敏感和耐药菌株的一致性均为1.00。
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