Blackwell J N, Finlayson N D, McLoughlin G P, Sumerling M D, Tothill P
Eur J Nucl Med. 1979 Feb 1;4(1):7-11. doi: 10.1007/BF00257562.
Iodine-131 labelled Biligram has been evaluated as a radiopharmaceutical for dynamic scintiscanning of the liver and biliary tract. In 10 normal subjects there was good visualisation of the liver and gallbladder. In 18 patients 131I Biligram was found to be unsatifactory for differentiating parenchymal liver disease from biliary tract obstruction owing to inability to demonstrate the gallbladder when liver function was more than mildly deranged. Quantitative analyses of blood clearance and hepatic activity curves for 131I Biligram were not clinically helpful. Urinary excretion of 131I Biligram increased with the degree of hepatic dysfunction.
碘-131标记的必利胆胺已被评估用作肝脏和胆道动态闪烁扫描的放射性药物。在10名正常受试者中，肝脏和胆囊显影良好。在18例患者中，由于肝功能出现中度以上紊乱时无法显示胆囊，发现131I必利胆胺在鉴别实质性肝病与胆道梗阻方面效果不佳。对131I必利胆胺的血液清除率和肝脏活性曲线进行的定量分析在临床上并无帮助。131I必利胆胺的尿排泄量随肝功能障碍程度的增加而增加。
