Taenzer V, Speck U, Wolf R
Rofo. 1977 Mar;126(3):262-7. doi: 10.1055/s-0029-1230576.
Pharmacokinetic data after injection of the new cholegraphic contrast medium iotroxic acid (Biliscopin) in man are reported and compared with the results of injections of ioglycamate and iodoxic acid. Iotroxic acid is less completely bound to plasma proteins than ioglycamate, but significancy more so than iodoxamate. Plasma protein binding depends on contrast concentration in the plasma, as does excretion in the urine. Biliary transport rate and maximal iodine concentration in the gall bladder are higher after injections of iotroxinate and iodoxamate than after ioglycamate.
本文报告了新型胆影造影剂碘托酸（Biliscopin）在人体注射后的药代动力学数据，并与碘甘氨酸盐和碘多酸注射的结果进行了比较。碘托酸与血浆蛋白的结合不如碘甘氨酸盐完全，但比碘多酸盐显著更完全。血浆蛋白结合取决于血浆中的造影剂浓度，尿液排泄也是如此。注射碘托酸盐和碘多酸盐后，胆汁转运速率和胆囊中的最大碘浓度高于注射碘甘氨酸盐后。
