The distribution of 75Se-adenosyl selenomethionine in the rat with observations on its potential as a prostate scanning agent.

The preparation of 75Se-adenosyl selenomethionine is described. Following injection into male rats 63% of the administered label was excreted in 24 h, predominantly in the urine. The remaining activity appeared to have joined the S-adenosyl methionine pool residing mainly in the liver and kidney. The maximum incorporation into the ventral prostate was 2 to 4 h after injection at 0.7% injected dose/g wet weight. These results indicate that 75Se-adenosyl selenomethionine is not a suitable radiopharmaceutical for diagnostic scanning of the prostate.