Cottrall M F, Taylor D M
Nuklearmedizin. 1981 Aug;20(4):187-90.
The influence of pre-treatment with a variety of agents on the uptake of 75Se-selenomethionine by the rat pancreas has been studied. The agents ranged from thyroid hormones to protein synthesis inhibitors but out of 16 tested, only propylthiouracyl (50 mg/kg i.p. administered for 3 days prior to 75Se-methionine injection) resulted in a significant increase in the pancreatic uptake (17%) and in the pancreas liver concentration ratio (25%). Seven of the agents resulted in significant reductions in the pancreas/liver concentration ratios. No significant effects were produced by the addition of carrier methionine or selenomethionine (in the range 10-250 micrograms/kg body weight) to the injected radiopharmaceutical. It was concluded that many factors may influence the uptake, but that the interrelationship of hypothalamus, pituitary and pancreas is of particular interest.
已经研究了用多种药剂进行预处理对大鼠胰腺摄取75Se-硒代蛋氨酸的影响。这些药剂从甲状腺激素到蛋白质合成抑制剂不等，但在16种受试药剂中，只有丙硫氧嘧啶（在注射75Se-蛋氨酸前3天腹腔注射50mg/kg）导致胰腺摄取量显著增加（17%），并且胰腺与肝脏的浓度比增加（25%）。其中7种药剂导致胰腺/肝脏浓度比显著降低。向注射的放射性药物中添加载体蛋氨酸或硒代蛋氨酸（体重10 - 250微克/千克范围内）未产生显著影响。得出的结论是，许多因素可能影响摄取，但下丘脑、垂体和胰腺之间的相互关系特别值得关注。
