淋巴细胞性脉络丛脑膜炎病毒导致新生大鼠小脑发育不全。
Cerebellar hypoplasia in neonatal rats caused by lymphocytic choriomeningitis virus.
作者信息
Monjan A A, Gilden D H, Cole G A, Nathnson N
出版信息
Science. 1971 Jan 15;171(3967):194-6. doi: 10.1126/science.171.3967.194.
PMID:4992415
Abstract
Lymphocytic choriomeningitis virus, strain E-350, when inoculated intracerebrally in rats 1 to 7 days old, produces an acute destructive infection of the cerebellar cortex resulting in permanent cerebellar hypoplasia and ataxia. Several other arenoviruses may produce a similar lesion in neonatal rodents.
摘要
淋巴细胞性脉络丛脑膜炎病毒E-350株，在1至7日龄大鼠脑内接种时，会引起小脑皮质的急性破坏性感染，导致永久性小脑发育不全和共济失调。其他几种沙粒病毒也可能在新生啮齿动物中产生类似病变。
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