博尔纳病病毒
Borna disease virus.
作者信息
Jordan I, Lipkin W I
机构信息
Emerging Diseases Laboratory, Department of Neurology, University of California-- Irvine, Irvine, California 92697-4292, USA.
出版信息
Rev Med Virol. 2001 Jan-Feb;11(1):37-57. doi: 10.1002/rmv.300.
Abstract
Borna disease virus (BDV) is unique amongst animal RNA viruses in its molecular biology and capacity to cause persistent, noncytolytic CNS-infection in a wide variety of host species. Unlike other non-segmented negative-strand RNA animal viruses, BDV replicates in the nucleus of the host cell where splicing is employed for expression of a very compact genome. Epidemiological studies indicate a broad host range and geographical distribution, and some investigators have proposed that human infection may result in neuropsychiatric disorders. Experimental Borna disease in neonatal and adult rats provides an intriguing model for immune-mediated disturbances of brain development and function.
摘要
博尔纳病病毒（BDV）在动物RNA病毒中独具特色，其分子生物学特性以及在多种宿主物种中引发持续性、非细胞溶解性中枢神经系统感染的能力均十分独特。与其他非节段性负链RNA动物病毒不同，BDV在宿主细胞核内复制，在此过程中通过剪接来表达一个非常紧凑的基因组。流行病学研究表明其宿主范围广泛且地理分布广泛，一些研究人员提出人类感染可能会导致神经精神障碍。新生和成年大鼠的实验性博尔纳病为免疫介导的脑发育和功能障碍提供了一个有趣的模型。
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Rev Med Virol. 2001 Jan-Feb;11(1):37-57. doi: 10.1002/rmv.300.
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No evidence for natural selection on endogenous borna-like nucleoprotein elements after the divergence of Old World and New World monkeys.在旧世界猴和新世界猴分化后，内源性博尔纳样核蛋白元件没有自然选择的证据。
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本文引用的文献
1
Isolation and characterization of a new subtype of Borna disease virus.博尔纳病病毒一种新亚型的分离与鉴定
J Virol. 2000 Jun;74(12):5655-8. doi: 10.1128/jvi.74.12.5655-5658.2000.
2
Demonstration of borna disease virus nucleic acid in a patient with chronic fatigue syndrome.慢性疲劳综合征患者中博尔纳病病毒核酸的检测
J Infect Dis. 2000 May;181(5):1860-2. doi: 10.1086/315474.
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Isolation of Borna disease virus from human brain tissue.从人类脑组织中分离出博尔纳病病毒。
J Virol. 2000 May;74(10):4601-11. doi: 10.1128/jvi.74.10.4601-4611.2000.
4
Expression and characterization of the Borna disease virus polymerase.博尔纳病病毒聚合酶的表达与特性分析
J Virol. 2000 May;74(9):4425-8. doi: 10.1128/jvi.74.9.4425-4428.2000.
5
Detection of Borna disease virus in a pregnant mare and her fetus.在一匹怀孕母马及其胎儿中检测到博尔纳病病毒。
Vet Microbiol. 2000 Mar 15;72(3-4):207-16. doi: 10.1016/s0378-1135(99)00206-0.
6
A short leucine-rich sequence in the Borna disease virus p10 protein mediates association with the viral phospho- and nucleoproteins.博尔纳病病毒p10蛋白中一段富含亮氨酸的短序列介导其与病毒磷酸蛋白和核蛋白的结合。
J Gen Virol. 2000 Apr;81(Pt 4):939-47. doi: 10.1099/0022-1317-81-4-939.
7
Characterization of the P protein-binding domain on the 10-kilodalton protein of Borna disease virus.博尔纳病病毒10千道尔顿蛋白上P蛋白结合结构域的特征分析
J Virol. 2000 Apr;74(7):3413-7. doi: 10.1128/jvi.74.7.3413-3417.2000.
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Distribution of Borna disease virus in the brain of rats infected with an obesity-inducing virus strain.博尔纳病病毒在感染致肥胖病毒株的大鼠脑中的分布。
Brain Pathol. 2000 Jan;10(1):39-48. doi: 10.1111/j.1750-3639.2000.tb00241.x.
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Sequence similarities between human bornavirus isolates and laboratory strains question human origin.人类博尔纳病毒分离株与实验室菌株之间的序列相似性对其人类起源提出了质疑。
Lancet. 1999 Dec 4;354(9194):1973-4. doi: 10.1016/S0140-6736(99)04703-0.
10
High prevalence of Borna disease virus in domestic cats with neurological disorders in Japan.日本患有神经疾病的家猫中博尔纳病病毒的高流行率。
Vet Microbiol. 1999 Dec;70(3-4):153-69. doi: 10.1016/s0378-1135(99)00135-2.
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