Hudson F R, Dewey D L, Galpine A R, Whittingham A G
Eur J Nucl Med. 1979 Aug 1;4(4):283-4. doi: 10.1007/BF00304884.
The uptake of 201Tl-chloride in tumours has recently been investigated in several authors' laboratories. We are reporting studies on the uptake in malignant melanoma in mice. Generally, we confirm the published data qualitatively in finding higher uptake in tumour than in muscles. We confirm the rapid blood clearance and high kidney concentration, but we did not measure the myocardial uptake. We observed the concentrations in kidney muscle and tumour to rise during the first four hours while that in the liver fell from one hour onwards. We did not observe markedly higher uptake in melanin rich tumour than in other tumours.
近期，多位作者的实验室对氯化铊-201在肿瘤中的摄取情况进行了研究。我们报告了关于小鼠恶性黑色素瘤摄取情况的研究。总体而言，我们定性地证实了已发表的数据，即肿瘤中的摄取量高于肌肉。我们证实了血液清除迅速且肾脏浓度较高，但未测量心肌摄取情况。我们观察到，在最初的四个小时内，肾脏、肌肉和肿瘤中的浓度升高，而肝脏中的浓度从一小时起开始下降。我们没有观察到富含黑色素的肿瘤比其他肿瘤有明显更高的摄取量。
