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一例伴有碳酸酐酶活性缺陷的失碳酸氢盐性肾小管性酸中毒病例。

A case of bicarbonate-losing renal tubular acidosis with defective carboanhydrase activity.

作者信息

Donckerwolcke R A, van Stekelenburg G J, Tiddens H A

出版信息

Arch Dis Child. 1970 Dec;45(244):769-73. doi: 10.1136/adc.45.244.769.

DOI:10.1136/adc.45.244.769
PMID:4992595
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1647400/
Abstract

A girl of 20 months had primary proximal renal tubular acidosis with a lowered renal threshold for bicarbonate. There was no carboanhydrase inhibition after acetazolamide administration, suggesting that defective carboanhydrase activity may have been causative.

摘要

一名20个月大的女童患有原发性近端肾小管酸中毒，碳酸氢盐肾阈值降低。给予乙酰唑胺后无碳酸酐酶抑制作用，提示碳酸酐酶活性缺陷可能是病因。

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A case of bicarbonate-losing renal tubular acidosis with defective carboanhydrase activity.一例伴有碳酸酐酶活性缺陷的失碳酸氢盐性肾小管性酸中毒病例。
Arch Dis Child. 1970 Dec;45(244):769-73. doi: 10.1136/adc.45.244.769.
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Effect of acetazolamide on renal bicarbonate reabsorption in volume-expanded dogs.
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本文引用的文献

1
Renal bicarbonate reabsorption and hydrogen ion excretion in normal infants.正常婴儿的肾碳酸氢盐重吸收和氢离子排泄。
J Clin Invest. 1967 Aug;46(8):1309-17. doi: 10.1172/JCI105623.
2
THE RENAL REGULATION OF ACID-BASE BALANCE IN MAN. III. THE REABSORPTION AND EXCRETION OF BICARBONATE.人体酸碱平衡的肾脏调节。III. 碳酸氢盐的重吸收与排泄。
J Clin Invest. 1949 Jan;28(1):35-44. doi: 10.1172/JCI102050.
3
Evaluation of the gastric Na:H exchange mechanism using histamine and diamox.使用组胺和乙酰唑胺评估胃钠氢交换机制。
Am J Physiol. 1962 Feb;202:293-301. doi: 10.1152/ajplegacy.1962.202.2.293.
4
THE MECHANISM OF BICARBONATE REABSORPTION IN THE PROXIMAL AND DISTAL TUBULES OF THE KIDNEY.肾脏近端小管和远端小管中碳酸氢根重吸收的机制
J Clin Invest. 1965 Feb;44(2):278-90. doi: 10.1172/JCI105142.
5
THE RENAL EXCRETION OF HYDROGEN IONS IN INFANTS AND CHILDREN.婴儿和儿童体内氢离子的肾脏排泄
Arch Dis Child. 1965 Feb;40(209):33-9. doi: 10.1136/adc.40.209.33.
6
Studies on the mechanism of bicarbonate reabsorption in man.人体碳酸氢盐重吸收机制的研究。
J Lab Clin Med. 1960 Aug;56:294-302.
7
Studies on renal enzymes in a patient with renal tubular acidosis.肾小管性酸中毒患者的肾脏酶学研究。
Am J Med. 1960 Jul;29:168-75. doi: 10.1016/0002-9343(60)90014-0.
8
The renal excretion of hydrogen ion in renal tubular acidosis. II. Quantitative response to the carbonic anhydrase inhibitor, acetazolamide.
Am J Med. 1960 Oct;29:576-85. doi: 10.1016/0002-9343(60)90091-7.
9
The role of plasma CO2 tension and carbonic anhydrase activity in the renal reabsorption of bicarbonate.血浆二氧化碳张力及碳酸酐酶活性在肾脏重吸收碳酸氢根中的作用
J Clin Invest. 1960 Nov;39(11):1706-21. doi: 10.1172/JCI104193.
10
The renal excretion of hydrogen ion in renal tubular acidosis. I. quantitative assessment of the response to ammonium chloride as an acid load.肾小管酸中毒时氢离子的肾排泄。I. 氯化铵作为酸负荷时反应的定量评估。
Am J Med. 1960 Oct;29:554-75. doi: 10.1016/0002-9343(60)90090-5.