Dominguez-Gil A, Lanao J M, Tabernero J M, Rodriguez Commes J L, de Castro S
Eur J Clin Pharmacol. 1979 Aug;16(1):49-52. doi: 10.1007/BF00644966.
The pharmacokinetics of cephacetrile were studied after its administration as a single i.v. bolus injection of 15 mg/kg body weight to 11 patients with terminal renal inpairment undergoing haemodialysis for 6 h. A two-compartment kinetic model was used to describe the biphasic decrease in plasma concentration. The quantities of antibiotic in the central and peripheral compartments, and the amounts eliminated, were calculated for different times. During haemodialysis sessions, the average pharmacokinetic parameters of cephacetrile determined at the dialyser input were: a = 5.03 h-1, beta = 0.458 h-1, K12 = 2.337 h-1, K21 = 1.996 h-1 K13 = 1.154 h-1, Vc = 5.5081, Vp = 6.4481, Vdss = 11.9561. As a function of the pharmacokinetic parameters of cephacetrile, a regimen of multiple doses was established for patients with terminal renal impairment, which will guarantee safe and effective concentrations of the antibiotic.
对11例终末期肾功能损害且正在接受6小时血液透析的患者，静脉注射15mg/kg体重的头孢乙腈单次推注后，研究了其药代动力学。采用二室动力学模型描述血浆浓度的双相下降。计算了不同时间中央室和外周室的抗生素量以及消除量。在血液透析期间，在透析器入口处测定的头孢乙腈平均药代动力学参数为：α = 5.03 h⁻¹，β = 0.458 h⁻¹，K12 = 2.337 h⁻¹，K21 = 1.996 h⁻¹，K13 = 1.154 h⁻¹，Vc = 5.508L，Vp = 6.448L，Vdss = 11.956L。根据头孢乙腈的药代动力学参数，为终末期肾功能损害患者制定了多剂量给药方案，该方案将保证抗生素的安全有效浓度。
