Garcia M J, Dominguez-Gil A, Tabernero J M, Bondia Román A
Int J Clin Pharmacol Biopharm. 1979 Aug;17(8):366-70.
The parmacokinetics of Cefoxitin were studied after an i.v. administration of 15 mg/kg body weight in 17 patients with terminal renal impairment, 10 of which were undergoing 6 hr hemodialysis sessions. The average pharmokinetic parameters obtained from this kind of patient were the following: alpha = 2.88 hr-1 beta = 0.18 hr-1 K12 = 1.43 hr-1 K21 = 1.04 hr-1 K13 = 0.53 hr-1 Vc = 8.23 l Vp = 11.61 l Vdss = 19.84 l. The amounts of the antibiotic in the central and peripheric compartments are established together with the amount of the antibiotic eliminated as a function of time. The pharmacokinetic parameters are significantly different from those established in the period between dialysis sessions, and thus, the elimination constant reaches a value of 0.28 h-1. The degree of plasma protein binding of Cefoxitin is 41.46% during the hemodialysis sessions. A dosage regimen is programmed as a function of the pharmacokinetic parameters established for this kind of patient. It is recommended that an i.v. dose of 15 mg/kg body weight should be administered at the beginning and end of each dialysis session lasting 6 hours, when the periods between the sessions are 48 hours.
在17例终末期肾功能损害患者中，静脉注射15mg/kg体重的头孢西丁后，对其药代动力学进行了研究，其中10例患者正在进行6小时的血液透析治疗。从这类患者中获得的平均药代动力学参数如下：α = 2.88小时-1，β = 0.18小时-1，K12 = 1.43小时-1，K21 = 1.04小时-1，K13 = 0.53小时-1，Vc = 8.23升，Vp = 11.61升，Vdss = 19.84升。确定了中央和外周室中抗生素的量以及作为时间函数消除的抗生素量。药代动力学参数与透析期间确定的参数有显著差异，因此，消除常数达到0.28小时-1的值。血液透析期间头孢西丁的血浆蛋白结合率为41.46%。根据为这类患者确定的药代动力学参数制定给药方案。建议当透析间隔为48小时时，在每次持续6小时的透析开始和结束时静脉注射15mg/kg体重的剂量。
