采用高效液相色谱法对尿中6β-羟基皮质醇进行定量测定，6β-羟基皮质醇是利福平及抗癫痫药物诱导酶的一个指标。 - Suppr

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超能文献

Quantitative determination by HPLC of urinary 6beta-hydroxycortisol, an indicator of enzyme induction by rifampicin and antiepileptic drugs.

作者信息

Roots I, Holbe R, Hövermann W, Nigam S, Heinemeyer G, Hildebrandt A G

出版信息

Eur J Clin Pharmacol. 1979 Aug;16(1):63-71. doi: 10.1007/BF00644969.

DOI:10.1007/BF00644969

PMID:499302

Abstract

摘要

相似文献

Quantitative determination by HPLC of urinary 6beta-hydroxycortisol, an indicator of enzyme induction by rifampicin and antiepileptic drugs.采用高效液相色谱法对尿中6β-羟基皮质醇进行定量测定，6β-羟基皮质醇是利福平及抗癫痫药物诱导酶的一个指标。

Eur J Clin Pharmacol. 1979 Aug;16(1):63-71. doi: 10.1007/BF00644969.

A comparison of 4β-hydroxycholesterol : cholesterol and 6β-hydroxycortisol : cortisol as markers of CYP3A4 induction.4β-羟胆固醇：胆固醇和 6β-羟皮质醇：皮质醇作为 CYP3A4 诱导标志物的比较。

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Pharmacokinetics of ruboxistaurin are significantly altered by rifampicin-mediated CYP3A4 induction.利福平介导的CYP3A4诱导可显著改变鲁比前列酮的药代动力学。

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The increase in urinary excretion of 6 beta-hydroxycortisol as a marker of human hepatic cytochrome P450IIIA induction.尿中6β-羟基皮质醇排泄增加作为人类肝细胞色素P450IIIA诱导的标志物。

Br J Clin Pharmacol. 1989 Oct;28(4):373-87. doi: 10.1111/j.1365-2125.1989.tb03516.x.

Urinary excretion of 6 beta-hydroxycortisol and the time course measurement of enzyme induction in man.人体中6β-羟基皮质醇的尿排泄及酶诱导的时间进程测量

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Comparison of endogenous 4β-hydroxycholesterol with midazolam as markers for CYP3A4 induction by rifampicin.比较内源性 4β-羟胆固醇与咪达唑仑作为利福平诱导 CYP3A4 的标志物。

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Effect of rifampin on apparent clearance of everolimus.利福平对依维莫司表观清除率的影响。

Ann Pharmacother. 2002 Jun;36(6):981-5. doi: 10.1345/aph.1A384.

Urinary 6beta-hydroxycortisol/17-hydroxycorticosteroids ratio as a measure of hepatic CYP3A4 capacity after enzyme induction.尿中6β-羟基皮质醇/17-羟基皮质类固醇比值作为酶诱导后肝脏CYP3A4能力的一项指标。

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Effect of troglitazone on urinary excretion of 6beta-hydroxycortisol.曲格列酮对6β-羟基皮质醇尿排泄的影响。

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Differential effects of Saint John's Wort (hypericum perforatum) on the urinary excretion of D-glucaric acid and 6beta-hydroxycortisol in healthy volunteers.圣约翰草（贯叶连翘）对健康志愿者尿中D -葡糖醛酸和6β -羟基皮质醇排泄的不同影响。

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Urinary 6beta-hydroxycortisol: a validated test for evaluating drug induction or drug inhibition mediated through CYP3A in humans and in animals.尿6β-羟基皮质醇：一种用于评估人类和动物中通过CYP3A介导的药物诱导或药物抑制作用的有效检测方法。

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Increases in metabolism of valproate and excretion of 6beta-hydroxycortisol in patients with traumatic brain injury.创伤性脑损伤患者丙戊酸盐代谢增加及6β-羟基皮质醇排泄增加。

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Lansoprazole does not affect the bioavailability of oral contraceptives.兰索拉唑不影响口服避孕药的生物利用度。

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Urinary excretion of D-glucaric acid, an indicator of drug metabolizing enzyme activity, in patients with impaired renal function.肾功能受损患者体内药物代谢酶活性指标D-葡萄糖醛酸的尿排泄情况。

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Assessment of urinary 6 beta-hydroxycortisol as an in vivo index of mixed-function oxygenase activity.评估尿6β-羟基皮质醇作为混合功能加氧酶活性的体内指标。

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A link between liver microsomal enzyme activity and thyroid hormone metabolism in man.人体肝脏微粒体酶活性与甲状腺激素代谢之间的联系。

Br J Clin Pharmacol. 1983 Jan;15(1):71-6. doi: 10.1111/j.1365-2125.1983.tb01466.x.

本文引用的文献

The physiologic significance of 6beta-hydroxycortisol in human corticoid metabolism.6β-羟基皮质醇在人体皮质类固醇代谢中的生理意义。

J Clin Endocrinol Metab. 1962 Jan;22:71-7. doi: 10.1210/jcem-22-1-71.

ALTERED CORTISOL METABOLISM IN ADVANCED CANCER AND OTHER TERMINAL ILLNESSES: EXCRETION OF 6-HYDROXYCORTISOL.晚期癌症及其他终末期疾病中皮质醇代谢的改变：6-羟基皮质醇的排泄

Metabolism. 1964 Dec;13:1425-38. doi: 10.1016/0026-0495(64)90036-8.

EFFECT OF DIPHENYLHYDANTOIN ON CORTISOL METABOLISM IN MAN.二苯乙内酰脲对人体皮质醇代谢的影响。

J Clin Invest. 1964 Sep;43(9):1824-35. doi: 10.1172/JCI105056.

6beta-Hydroxycortisol and other polar corticosteroids: measurement and significance in human urine.6β-羟基皮质醇及其他极性皮质类固醇：人尿中的测定及其意义

J Clin Endocrinol Metab. 1961 Oct;21:1290-303. doi: 10.1210/jcem-21-10-1290.

6-beta-hydroxy-cortisol: high levels in human urine in pregnancy and toxemia.6-β-羟基皮质醇：孕期及毒血症患者尿液中含量升高。

Proc Soc Exp Biol Med. 1960 Oct;105:41-3. doi: 10.3181/00379727-105-26002.

The determination of 17,21-dihydroxy-20-ketosteroids in urine and plasma.尿液和血浆中17,21 - 二羟基 - 20 - 酮类固醇的测定

J Biol Chem. 1954 Oct;210(2):923-32.

A study of liquid chromatography in columns. The time of separation.柱中液相色谱研究。分离时间。

Anal Chim Acta. 1967 May-Jun;38(1):305-13. doi: 10.1016/s0003-2670(01)80592-4.

[Quantitative determination of 6 beta-hydroxycortisol during application of thin layer chromatography with fluorescence indicator].[应用带荧光指示剂的薄层色谱法时6β-羟基皮质醇的定量测定]

Z Klin Chem Klin Biochem. 1966 May;4(3):130-3.

Urinary excretion of 6 beta-hydroxycortisol in states of altered thyroid function.甲状腺功能改变状态下6β-羟基皮质醇的尿排泄情况。

J Clin Endocrinol Metab. 1969 Jun;29(6):801-6. doi: 10.1210/jcem-29-6-801.

A comparison of gas-liquid chromatography with colorimetric methods for the estimation of extremely polar unconjugated corticosteroids in urine.气相色谱法与比色法在尿液中极极性未结合皮质类固醇测定中的比较。

Steroids. 1969 Feb;13(2):247-55. doi: 10.1016/0039-128x(69)90010-5.

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