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核受累提示x病毒感染。 （原英文表述似乎有误，推测正确表述可能是“Nuclear involvement points to x virus infection.” ）

Nuclear involvement poin xvirus infection.

作者信息

Walen K H

出版信息

Proc Natl Acad Sci U S A. 1971 Jan;68(1):165-8. doi: 10.1073/pnas.68.1.165.

DOI:10.1073/pnas.68.1.165
PMID:4993213
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC391187/
Abstract

During the first hours of infection with vaccinia virus, part of the chromosomal DNA of host cells is degraded, part of it is released from the cell, and part of it eventually appears in cytoplasmic foci associated with the reproduction of virus. The DNA of the infecting particle is first found attached to the chromosomes. Intranuclear foci of DNA incorporation appear later; these rapidly move out into the perinuclear space and eventually become typical cytoplasmic "virus factories." Each of these observations points to a more direct involvement of the nucleus in viral infection than was previously envisaged.

摘要

在感染痘苗病毒的最初几个小时内，宿主细胞的部分染色体DNA会被降解，部分会从细胞中释放出来，还有部分最终会出现在与病毒繁殖相关的细胞质病灶中。感染颗粒的DNA最初被发现附着在染色体上。随后会出现DNA整合的核内病灶；这些病灶迅速移至核周空间，最终成为典型的细胞质“病毒工厂”。这些观察结果均表明，细胞核在病毒感染中的参与程度比之前设想的更为直接。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66b7/391187/386f28dc92ff/pnas00076-0174-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66b7/391187/8d00cf95dff0/pnas00076-0174-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66b7/391187/26bf283ae39d/pnas00076-0174-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66b7/391187/040295b77a9b/pnas00076-0174-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66b7/391187/386f28dc92ff/pnas00076-0174-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66b7/391187/8d00cf95dff0/pnas00076-0174-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66b7/391187/26bf283ae39d/pnas00076-0174-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66b7/391187/040295b77a9b/pnas00076-0174-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66b7/391187/386f28dc92ff/pnas00076-0174-d.jpg

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引用本文的文献

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Infect Immun. 1973 Apr;7(4):532-8. doi: 10.1128/iai.7.4.532-538.1973.
3
Intracellular location of rabbit poxvirus nucleic acid within infected cells as determined by in situ hybridization.通过原位杂交确定兔痘病毒核酸在受感染细胞内的细胞定位。

本文引用的文献

1
The synthesis of vaccinial deoxyribonucleic acid.牛痘脱氧核糖核酸的合成
Virology. 1960 May;11:296-9. doi: 10.1016/0042-6822(60)90070-2.
2
THE INTRACELLULAR FATE OF RABBITPOX VIRUS RENDERED NONINFECTIOUS BY VARIOUS REAGENTS.经各种试剂处理后失去感染性的兔痘病毒在细胞内的命运
Virology. 1964 Apr;22:620-33. doi: 10.1016/0042-6822(64)90084-4.
3
Biochemistry of vaccinia-infected mouse fibroblasts (strain L-M). II. Properties of the chromosomal DNA of infected cells.牛痘感染的小鼠成纤维细胞（L-M株）的生物化学。II. 感染细胞染色体DNA的特性。
J Virol. 1985 Sep;55(3):634-43. doi: 10.1128/JVI.55.3.634-643.1985.
4
Failure of poxvirus replication in the presence of an inhibitor of nucleolar RNA synthesis.在存在核仁RNA合成抑制剂的情况下痘病毒复制失败。
Arch Virol. 1977;53(1-2):163-6. doi: 10.1007/BF01314857.
5
Vaccinia virus infection of HeLa cells. I. Synthesis of vaccinia DNA in host cell nuclei.痘苗病毒对HeLa细胞的感染。I. 宿主细胞核中痘苗病毒DNA的合成
J Virol. 1975 Feb;15(2):305-15. doi: 10.1128/JVI.15.2.305-315.1975.
6
Vaccinia virus replication. I. Requirement for the host-cell nucleus.牛痘病毒复制。I. 对宿主细胞核的需求。
J Virol. 1979 Feb;29(2):705-15. doi: 10.1128/JVI.29.2.705-715.1979.
Virology. 1962 Oct;18:286-93. doi: 10.1016/0042-6822(62)90015-6.
4
An autoradiographic study on the intracellular development of vaccinia virus.一项关于痘苗病毒细胞内发育的放射自显影研究。
Virology. 1961 Oct;15:146-63. doi: 10.1016/0042-6822(61)90231-8.
5
The initiation of vaccinia infection.牛痘感染的起始
Virology. 1960 Jul;11:603-23. doi: 10.1016/0042-6822(60)90103-3.
6
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Cystathioninuria: nature of the defect.胱硫醚尿症：缺陷的本质。
Science. 1965 Sep 3;149(3688):1095-6. doi: 10.1126/science.149.3688.1095.
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Prog Med Virol. 1965;7:1-43.