Hall W H, Manion R E
Appl Microbiol. 1970 Oct;20(4):600-4. doi: 10.1128/am.20.4.600-604.1970.
A series of 27 strains of six species of Brucella was tested for susceptibility in vitro to a representative cross section of antibiotics in current use. The activity against each species was plotted, with the cumulative per cent of strains inhibited indicated for each concentration. As a class, the tetracycline antibiotics were the most effective. Erythromycin, gentamicin, streptomycin, and kanamycin, as well as rifampin, were quite active. The penicillin-cephalosporin group, with the exception of ampicillin, was comparatively ineffective, as were the polypeptides and the miscellaneous group of chloramphenicol, lincomycin, cycloserine, and sulfadiazine. Species differences were noticeable, with some strains of B. canis being considerably more resistant to streptomycin and the tetracyclines than B. suis and B. abortus. B. melitensis, B. ovis, and B. neotomae were intermediate in antibiotic susceptibility.
对27株六种布鲁氏菌进行了体外试验，检测它们对目前使用的具有代表性的一系列抗生素的敏感性。绘制了每种抗生素对各个菌种的活性曲线，并标明了每种浓度下被抑制菌株的累积百分比。总体而言，四环素类抗生素最为有效。红霉素、庆大霉素、链霉素、卡那霉素以及利福平也相当有效。除氨苄西林外，青霉素 - 头孢菌素类相对无效，多肽类以及氯霉素、林可霉素、环丝氨酸和磺胺嘧啶等其他类抗生素也无效。菌种间差异明显，一些犬布鲁氏菌菌株对链霉素和四环素的耐药性比猪布鲁氏菌和流产布鲁氏菌强得多。马尔他布鲁氏菌、绵羊布鲁氏菌和新墨西哥布鲁氏菌的抗生素敏感性处于中等水平。
