关于被膜小泡在再生禽羽黑素生成中的可能作用
On the possible function of coated vesicles in melanogenesis of the regenerating fowl feather.
作者信息
Maul G G, Brumbaugh J A
出版信息
J Cell Biol. 1971 Jan;48(1):41-8. doi: 10.1083/jcb.48.1.41.
Abstract
How tyrosinase becomes associated with the premelanosomes was investigated by histochemical demonstration of tyrosinase activity by the use of dihydroxyphenylalanine (DOPA) in melanocytes of regenerating fowl feathers. The reaction product of DOPA was localized in the anastomosing membrane tubules associated with the concave side of some dictyosomes of the Golgi apparatus and in coated vesicles most of which were in connection with the dictyosomes. No reaction product was found in early premelanosomes. In premelanosomes, the reaction product of DOPA appears first in vesicles approximately 400 A in diameter which are surrounded by a matrix with a characteristic periodicity. These observations seem to allow the speculation that the coated vesicles function in the transport of tyrosinase, and that the premelanosomes are formed in a process which is not necessarily dependent on the Golgi apparatus as was assumed earlier.
摘要
通过在再生禽羽毛的黑素细胞中使用二羟基苯丙氨酸（多巴）对酪氨酸酶活性进行组织化学证明，研究了酪氨酸酶如何与前黑素小体相关联。多巴的反应产物定位于与高尔基体一些高尔基体凹面相关的吻合膜小管中以及大多数与高尔基体相连的有被小泡中。在早期前黑素小体中未发现反应产物。在前黑素小体中，多巴的反应产物首先出现在直径约400埃的小泡中，这些小泡被具有特征性周期性的基质包围。这些观察结果似乎可以推测，有被小泡在酪氨酸酶的运输中起作用，并且前黑素小体是在一个不一定像早期所假设的那样依赖高尔基体的过程中形成的。
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