前列腺素F2-α对犬脾脏血管及包膜平滑肌的作用。
Actions of prostaglandin F2-alpha on the splenic vascular and capsular smooth muscle in the dog.
作者信息
Davies B N, Withrington P G
出版信息
Br J Pharmacol. 1971 Jan;41(1):1-7. doi: 10.1111/j.1476-5381.1971.tb09929.x.
Abstract
- The actions of prostaglandin F(2alpha), which is known to be released by the spleen on sympathetic nerve stimulation, have been investigated in the isolated blood perfused spleen of the dog.2. Low arterial concentrations of F(2alpha) (less than 10 mug/100 ml) caused marked reductions in splenic vascular resistance.3. High arterial concentrations of F(2alpha) (above 10 mug/100 ml) caused increases in splenic vascular resistance.4. Little action on splenic volume was observed by any arterial concentration of F(2alpha).5. The reductions in splenic vascular resistance caused by low arterial concentrations of F(2alpha) were reversed by blocking doses of phenoxybenzamine.6. No appreciable interaction between F(2alpha) and the splenic responses to sympathetic nerve stimulation, adrenaline and noradrenaline was observed.7. The role of the prostaglandins released by the spleen is discussed.
摘要
已知前列腺素F(2α)在交感神经刺激下由脾脏释放，其作用已在犬离体血液灌注脾脏中进行了研究。
低动脉浓度的F(2α)（低于10微克/100毫升）可导致脾血管阻力显著降低。
高动脉浓度的F(2α)（高于10微克/100毫升）可导致脾血管阻力增加。
任何动脉浓度的F(2α)对脾体积均无明显作用。
低动脉浓度的F(2α)引起的脾血管阻力降低可被阻断剂量的酚苄明逆转。
未观察到F(2α)与脾脏对交感神经刺激、肾上腺素和去甲肾上腺素的反应之间有明显相互作用。
讨论了脾脏释放的前列腺素的作用。
相似文献
1
Actions of prostaglandin F2-alpha on the splenic vascular and capsular smooth muscle in the dog.前列腺素F2-α对犬脾脏血管及包膜平滑肌的作用。
Br J Pharmacol. 1971 Jan;41(1):1-7. doi: 10.1111/j.1476-5381.1971.tb09929.x.
2
Frequency-dependent differences in the responses of the capsular and vascular smooth muscle of the spleen of the dog to sympathetic nerve stimulation.犬脾脏被膜和血管平滑肌对交感神经刺激反应的频率依赖性差异。
J Physiol. 1973 Jan;228(1):13-25. doi: 10.1113/jphysiol.1973.sp010069.
3
Responses of the isolated, perfused human spleen to sympathetic nerve stimulation, catecholamines and polypeptides.离体灌注人脾脏对交感神经刺激、儿茶酚胺和多肽的反应。
Br J Pharmacol. 1972 Jan;44(1):17-30. doi: 10.1111/j.1476-5381.1972.tb07234.x.
4
The effects of prostaglandins E1 and E2 on the smooth muscle of the dog spleen and on its responses to catecholamines, angiotensin and nerve stimulation.前列腺素E1和E2对犬脾脏平滑肌及其对儿茶酚胺、血管紧张素和神经刺激反应的影响。
Br J Pharmacol Chemother. 1968 Jan;32(1):136-44. doi: 10.1111/j.1476-5381.1968.tb00437.x.
5
The responses of the isolated, blood-perfused spleen of the dog to angiotensin, oxytocin and vasopressin.犬离体血液灌注脾脏对血管紧张素、催产素和加压素的反应。
Br J Pharmacol. 1975 Jun;54(2):205-12. doi: 10.1111/j.1476-5381.1975.tb06930.x.
6
7
The actions of endothelins-1 and -3 on the vascular and capsular smooth muscle of the isolated blood perfused spleen of the dog.内皮素-1和内皮素-3对犬离体血液灌注脾脏的血管和平滑肌囊的作用。
Br J Pharmacol. 1992 Feb;105(2):490-4. doi: 10.1111/j.1476-5381.1992.tb14281.x.
8
The differential effect of cooling on the responses of splenic capsular and vascular smooth muscle to nerve stimulation and noradrenaline.冷却对脾包膜和血管平滑肌对神经刺激及去甲肾上腺素反应的差异效应。
Pflugers Arch. 1978 Oct 18;377(1):87-94. doi: 10.1007/BF00584379.
9
Modulation by endogenous prostanoids of the vasoconstrictor activity of endothelin-1 in the canine isolated, perfused spleen.内源性前列腺素对犬离体灌注脾脏中内皮素-1血管收缩活性的调节作用。
Br J Pharmacol. 1994 Nov;113(3):675-80. doi: 10.1111/j.1476-5381.1994.tb17045.x.
10
The occurrence of prostaglandin E2 in splenic venous blood of the dog following splenic nerve stimulation.犬脾神经刺激后脾静脉血中前列腺素E2的出现情况。
Br J Pharmacol Chemother. 1968 Jan;32(1):127-35. doi: 10.1111/j.1476-5381.1968.tb00436.x.
引用本文的文献
1
The effect of indomethacin on the release of prostaglandin E2 and acetylcholine from guinea-pig isolated ileum at rest and during field stimulation.吲哚美辛对豚鼠离体回肠在静息状态及场刺激期间前列腺素E2和乙酰胆碱释放的影响。
Br J Pharmacol. 1974 Jan;50(1):119-24. doi: 10.1111/j.1476-5381.1974.tb09598.x.
2
Innervation and vascular pharmacodynamics of the mammalian spleen.哺乳动物脾脏的神经支配与血管药效学
Experientia. 1985 Feb 15;41(2):187-92. doi: 10.1007/BF02002612.
3
Prostaglandin release from cat and dog spleen.猫和狗脾脏中前列腺素的释放
Br J Pharmacol. 1975 Aug;54(4):499-505. doi: 10.1111/j.1476-5381.1975.tb07597.x.
本文引用的文献
1
Prostaglandins: their disappearance from and release into the circulation.前列腺素：它们在循环系统中的消失与释放
Nature. 1967 Dec 2;216(5118):868-73. doi: 10.1038/216868a0.
2
Effect of nerve stimulation on prostaglandin formation and release from the rat stomach.神经刺激对大鼠胃中前列腺素形成和释放的影响。
Am J Physiol. 1967 Oct;213(4):1056-64. doi: 10.1152/ajplegacy.1967.213.4.1056.
3
Prostaglandins released by the spleen.脾脏释放的前列腺素。
Nature. 1968 Jun 22;218(5147):1135-40. doi: 10.1038/2181135a0.
4
5
The occurrence of prostaglandin E2 in splenic venous blood of the dog following splenic nerve stimulation.犬脾神经刺激后脾静脉血中前列腺素E2的出现情况。
Br J Pharmacol Chemother. 1968 Jan;32(1):127-35. doi: 10.1111/j.1476-5381.1968.tb00436.x.
6
Hypotheses on physiological roles of prostaglandins.关于前列腺素生理作用的假说。
Physiol Rev. 1969 Jan;49(1):122-61. doi: 10.1152/physrev.1969.49.1.122.
7
The effects of prostaglandins E1 and E2 on the smooth muscle of the dog spleen and on its responses to catecholamines, angiotensin and nerve stimulation.前列腺素E1和E2对犬脾脏平滑肌及其对儿茶酚胺、血管紧张素和神经刺激反应的影响。
Br J Pharmacol Chemother. 1968 Jan;32(1):136-44. doi: 10.1111/j.1476-5381.1968.tb00437.x.
Zotero 插件