猫和狗脾脏中前列腺素的释放
Prostaglandin release from cat and dog spleen.
作者信息
Bedwani J R, Millar G C
出版信息
Br J Pharmacol. 1975 Aug;54(4):499-505. doi: 10.1111/j.1476-5381.1975.tb07597.x.
Abstract
- The output of prostaglandins from the spleens of cats and dogs was studied. Comparison is made between the results found in the two species. 2. The release of prostaglandins was investigated in isolated saline-perfused spleens and in incubates of spleen slices. Release in response to nerve stimulation, and exposure to adrenaline or noradrenaline was compared with resting release. 3. A resting release of prostaglandins was found in the dog but not in the cat spleen. 4. Whereas stimulated dog spleens released microgram quantities of prostaglandins E2 and F2alpha, prostaglandin output from the cat spleen under similar conditions was undectectable or barely detectable. 5. The identity of the prostaglandins released from the dog spleen (prostaglandins E2 and F2alpha) was confirmed by mass spectrometry. 6. The species difference in prostaglandin output from the spleen is discussed in relation to the hypothesis that endogenous prostaglandins modify the responses of this organ to nervous stimuli.
摘要
- 对猫和狗脾脏中前列腺素的产生进行了研究。比较了在这两个物种中发现的结果。2. 在离体盐水灌注脾脏和脾切片孵育物中研究了前列腺素的释放。将神经刺激、肾上腺素或去甲肾上腺素刺激后的释放与静息释放进行了比较。3. 在狗脾脏中发现有前列腺素的静息释放，但猫脾脏中未发现。4. 刺激后的狗脾脏释放微克量的前列腺素E2和F2α，而在类似条件下猫脾脏的前列腺素产量无法检测到或仅勉强可检测到。5. 通过质谱法确认了从狗脾脏释放的前列腺素（前列腺素E2和F2α）的身份。6. 结合内源性前列腺素改变该器官对神经刺激反应的假说，讨论了脾脏前列腺素产生的物种差异。
相似文献
1
Prostaglandin release from cat and dog spleen.猫和狗脾脏中前列腺素的释放
Br J Pharmacol. 1975 Aug;54(4):499-505. doi: 10.1111/j.1476-5381.1975.tb07597.x.
2
Hydrocortisone and the release of prostaglandins from spleen.
Prostaglandins. 1977 Jan;13(1):125-9. doi: 10.1016/0090-6980(77)90049-1.
3
Release of prostaglandins evoked by neurohormonal stimuli in the isolated spleen of rabbit.兔离体脾脏中神经激素刺激引起的前列腺素释放。
Eur J Pharmacol. 1980 Mar 7;62(1):97-105. doi: 10.1016/0014-2999(80)90485-9.
4
Some effects of inhibiting endogenous prostaglandin formation on the responses of the cat spleen.抑制内源性前列腺素形成对猫脾脏反应的某些影响。
Br J Pharmacol. 1973 Jan;47(1):48-58. doi: 10.1111/j.1476-5381.1973.tb08157.x.
5
On the relation between release of prostaglandins and contractility of rabbit splenic capsular strips.关于前列腺素释放与兔脾包膜条收缩性之间的关系。
Naunyn Schmiedebergs Arch Pharmacol. 1976;292(1):35-42. doi: 10.1007/BF00506487.
6
Effects of nerve stimulation and of administration of noradrenaline or potassium chloride upon the release of prostaglandins, I2, E2, and F2 alpha from te perfused mesenteric arterial bed of the rabbit.神经刺激以及去甲肾上腺素或氯化钾给药对兔肠系膜动脉床灌注液中前列腺素I2、E2和F2α释放的影响。
Br J Pharmacol. 1981 Jan;72(1):89-93. doi: 10.1111/j.1476-5381.1981.tb09109.x.
7
Evidence against a physiological role of prostaglandins in the regulation of noradrenaline release in the cat spleen.关于前列腺素在猫脾脏去甲肾上腺素释放调节中生理作用的反对证据。
J Physiol. 1975 Oct;251(3):737-62. doi: 10.1113/jphysiol.1975.sp011119.
8
Actions of prostaglandin F2-alpha on the splenic vascular and capsular smooth muscle in the dog.前列腺素F2-α对犬脾脏血管及包膜平滑肌的作用。
Br J Pharmacol. 1971 Jan;41(1):1-7. doi: 10.1111/j.1476-5381.1971.tb09929.x.
9
Release of noradrenaline from the cat spleen by nerve stimulation and potassium.通过神经刺激和钾离子从猫脾脏释放去甲肾上腺素。
J Physiol. 1976 Oct;261(2):301-17. doi: 10.1113/jphysiol.1976.sp011560.
10
Release of noradrenaline and dopamine by nerve stimulation in the cat spleen perfused with 3 H-dopamine.用3H-多巴胺灌注的猫脾脏中，神经刺激引起去甲肾上腺素和多巴胺的释放。
Br J Pharmacol. 1971 Sep;43(1):86-96. doi: 10.1111/j.1476-5381.1971.tb07159.x.
引用本文的文献
1
Urinary lipid production profile in canine patients with splenic mass.犬脾脏肿大患者尿液脂质产生谱。
J Vet Med Sci. 2022 Nov 1;84(11):1480-1484. doi: 10.1292/jvms.22-0355. Epub 2022 Sep 6.
2
Modulation on neuromuscular transmission by endogenous and exogenous prostaglandins in the guinea-pig mesenteric artery.内源性和外源性前列腺素对豚鼠肠系膜动脉神经肌肉传递的调节作用。
J Physiol. 1982 Jun;327:431-48. doi: 10.1113/jphysiol.1982.sp014241.
3
Stimulation of prostaglandin E2-synthesis by noradrenaline in primary cell cultures from rabbit splenic pulpa is mediated by atypical alpha-adrenoceptors.去甲肾上腺素对兔脾髓原代细胞培养物中前列腺素E2合成的刺激作用是由非典型α-肾上腺素能受体介导的。
Naunyn Schmiedebergs Arch Pharmacol. 1981 Feb;316(1):1-7. doi: 10.1007/BF00507219.
4
Prostaglandin-induced inhibition of acetylcholine release from neuronal elements of dog tracheal tissue.前列腺素对犬气管组织神经元成分中乙酰胆碱释放的诱导抑制作用。
J Physiol. 1984 Apr;349:553-70. doi: 10.1113/jphysiol.1984.sp015173.
5
Effects of prostaglandin E2 and a prostaglandin endoperoxide analogue on neuroeffector transmission in the rat anococcygeus msucle.前列腺素E2和一种前列腺素内过氧化物类似物对大鼠肛门尾骨肌神经效应器传递的影响。
Br J Pharmacol. 1978 May;63(1):167-76. doi: 10.1111/j.1476-5381.1978.tb07786.x.
本文引用的文献
1
Prostaglandins: their disappearance from and release into the circulation.前列腺素：它们在循环系统中的消失与释放
Nature. 1967 Dec 2;216(5118):868-73. doi: 10.1038/216868a0.
2
Effect of nerve stimulation on prostaglandin formation and release from the rat stomach.神经刺激对大鼠胃中前列腺素形成和释放的影响。
Am J Physiol. 1967 Oct;213(4):1056-64. doi: 10.1152/ajplegacy.1967.213.4.1056.
3
The occurrence of prostaglandin E2 in splenic venous blood of the dog following splenic nerve stimulation.犬脾神经刺激后脾静脉血中前列腺素E2的出现情况。
J Physiol. 1967 Jan;188(2):38P-39P.
4
Modulating effect of prostaglandin E2 on noradrenaline release from the isolated cat spleen.前列腺素E2对离体猫脾脏去甲肾上腺素释放的调节作用。
Acta Physiol Scand. 1969 Mar;75(3):511-2. doi: 10.1111/j.1748-1716.1969.tb04404.x.
5
Inhibition by prostaglandin E1 of noradrenaline release and of effector response to nerve stimulation in the cat spleen.前列腺素E1对猫脾脏中去甲肾上腺素释放及神经刺激效应反应的抑制作用。
Life Sci. 1969 Apr 1;8(7):389-95. doi: 10.1016/0024-3205(69)90232-x.
6
Prostaglandins released by the spleen.脾脏释放的前列腺素。
Nature. 1968 Jun 22;218(5147):1135-40. doi: 10.1038/2181135a0.
7
Inhibition of the release of adrenergic transmitter by a fatty acid in the perfusate from sympathetically stimulated rabbit heart.
Life Sci I. 1971 Apr 15;10(8):471-9. doi: 10.1016/0024-3205(71)90113-5.
8
The separation, identification and estimation of prostaglandins in nanogram quantities by combined gas chromatography-mass spectrometry.通过气相色谱-质谱联用技术对纳克量前列腺素进行分离、鉴定和定量分析。
Life Sci I. 1970 Sep 1;9(17):983-8. doi: 10.1016/0024-3205(70)90121-9.
9
Release of prostaglandin-like material from dog kidney during nerve stimulation.神经刺激期间犬肾中类前列腺素物质的释放。
Am J Physiol. 1970 Nov;219(5):1279-85. doi: 10.1152/ajplegacy.1970.219.5.1279.
10
Indomethacin and aspirin abolish prostaglandin release from the spleen.吲哚美辛和阿司匹林可抑制前列腺素从脾脏释放。
Nat New Biol. 1971 Jun 23;231(25):237-9. doi: 10.1038/newbio231237a0.
Zotero 插件