新型免疫调节化合物BM 12.531降低环磷酰胺和X射线的急性毒性
Reduction of acute toxicity of cyclophosphamide and X-rays by the new immunomodulating compound BM 12.531.
作者信息
Bicker U, Friedberg K D, Hebold G, Mengel K
出版信息
Experientia. 1979 Oct 15;35(10):1361-3. doi: 10.1007/BF01964009.
PMID:499423
Abstract
BM 12.531, the 2-[2-cyanaziridinyl-(1)]-2-[2-carbamoylaziridinyl-(1)]-propane, (prop. INN Azimexon), reduces significantly the acute toxicity of cyclophosphamide and X-rays in rats and mice, respectively. The leucopenia induced by X-rays was partially compensated by BM 12.531 in rats.
摘要
BM 12.531，即2-[2-氰基氮丙啶基-(1)]-2-[2-氨基甲酰基氮丙啶基-(1)]-丙烷（国际非专利药品名称为阿齐美克松），分别显著降低了环磷酰胺对大鼠和X射线对小鼠的急性毒性。在大鼠中，BM 12.531部分补偿了X射线诱导的白细胞减少。
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