BM 12.531（阿齐美克松）对正常或荷瘤小鼠的免疫调节作用：体外和体内研究。

The immunomodulatory effect on BM 12.531 (azimexon) on normal or tumored mice: in vitro and in vivo studies.

作者信息

Stylos W A, Chirigos M A, Papademetriou V, Lauer L

出版信息

J Immunopharmacol. 1980;2(1):113-32. doi: 10.3109/08923978009026392.

PMID:7452003

Abstract

The effect of BM 12.531 (BM) treatment on normal or tumored mice was studied under both in vitro and in vivo experimental conditions. It was found that BM treatment of mice that received 500 R of whole body irradiation caused a highly significant (P < 0.001) increase in the prolongation of the mean survival time. BM was found to significantly increase (P < 0.01) the delayed-type hypersensitivity reaction of normal mice. BM treatment was found to moderately increase both in vivo and in vitro activated macrophages. However, BM was found to be extremely effective in significantly increasing the mean survival times of lung carcinoma-bearing or leukemic mice.

摘要

在体外和体内实验条件下，研究了BM 12.531（BM）处理对正常或患瘤小鼠的影响。结果发现，对接受500伦琴全身照射的小鼠进行BM处理后，其平均存活时间的延长具有高度显著性（P < 0.001）。发现BM能显著增加（P < 0.01）正常小鼠的迟发型超敏反应。发现BM处理能适度增加体内和体外活化的巨噬细胞。然而，发现BM在显著增加荷肺癌或白血病小鼠的平均存活时间方面极其有效。