血清M成分患者的异常尿蛋白

Anomalous urinary proteins in patients with serum M-components.

作者信息

Pruzanski W, Ogryzlo M A

出版信息

Can Med Assoc J. 1971 Apr 3;104(7):581-8.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1930979/

Abstract

Abnormal urinary proteins were investigated in 365 patients with serum M-components; 250 urines were available for study. All specimens were concentrated and processed by electrophoresis and immunoelectrophoresis. An overall frequency of Bence Jones proteinuria was found in 63%, whereas other M-components were detected in 18%. In patients with multiple myeloma, Bence Jones proteinuria occurred in 71%, while M-components in the form of whole molecules of immunoglobulins or as Fc and F'c fragments were observed in 20%. Bence Jones globulin was found in 60% of patients with IgG myeloma, 69% of those with IgA myeloma and 100% of patients with IgD myeloma and light chain disease. In regard to other diseases, Bence Jones proteinuria was found in 44% of patients with macroglobulinemia, in 60% of patients with nonplasmacytic neoplastic diseases and in 28% of patients with non-malignant conditions. Other M-components were detected in the urine of 13%, 14% and 6% respectively.The detection of abnormal urinary proteins in patients with M-components in the serum is an important diagnostic tool and may have prognostic significance.

摘要

对365例血清M成分异常的患者进行了尿蛋白异常检测；共250份尿液可供研究。所有标本均经浓缩，并进行电泳和免疫电泳分析。本-周蛋白尿的总体发生率为63%，而其他M成分的检出率为18%。在多发性骨髓瘤患者中，本-周蛋白尿的发生率为71%，而以免疫球蛋白全分子形式或Fc和F'c片段形式存在的M成分的检出率为20%。在IgG骨髓瘤患者中，本-周球蛋白的检出率为60%，IgA骨髓瘤患者中为69%，IgD骨髓瘤和轻链病患者中为100%。在其他疾病中，巨球蛋白血症患者中本-周蛋白尿的检出率为44%，非浆细胞性肿瘤疾病患者中为60%，非恶性疾病患者中为28%。其他M成分在尿液中的检出率分别为13%、14%和6%。血清中存在M成分的患者尿中异常蛋白的检测是一项重要的诊断工具，可能具有预后意义。