Creyssel R, Gibaud A, Cordier J F, Boissel J P
Biomedicine. 1975 Jan;22(1):41-8.
In 1000 patients with monoclonal gammapathies, heavy and light chains typing of the monoclonal Ig was performed. Class distribution of the heavy chains showed the following percentages : IgG = 56.60%; IgA = 17.0%; IgM = 14.5%; IgD = 0.3%; Light chain gammapathies (including Bence-Jones proteinuria without serum M-component) = 11.6%. The chi/lambda ratio was 663/337. Such results agree with figures from most statistical studies. Beside the well-known linkage between IgM and chi types in pathological macroglobulinemia, the quite high incidence of lambda chain type of light chain components is to be noticed. The frequency of gamma G type of M-component is significantly higher in patients demonstrating no symptoms of myeloma or lymphoma. chi/lambda ratio seems to be slightly affected by aetiological features.
对1000例单克隆丙种球蛋白病患者的单克隆免疫球蛋白进行了重链和轻链分型。重链的类别分布显示出以下百分比：IgG = 56.60%；IgA = 17.0%；IgM = 14.5%；IgD = 0.3%；轻链型丙种球蛋白病（包括无血清M成分的本周蛋白尿） = 11.6%。κ/λ比例为663/337。这些结果与大多数统计研究的数据一致。除了病理巨球蛋白血症中IgM与κ型之间众所周知的关联外，轻链成分的λ链型发生率相当高也值得注意。在未表现出骨髓瘤或淋巴瘤症状的患者中，M成分的γG型频率明显更高。κ/λ比例似乎受病因特征的轻微影响。
