[Role of serotoninergic mechanisms in realizing the influence of diazepam on the effect of self-stimulation].

It has been shown in experiments on rats that diazepam (I mg/kg) abolishes an inhibitory action of cytalopram, the serotonine reverse uptake inhibitor (10 mg/kg) on the self-stimulation effect. Activation of self-stimulation was observed during diazepam action and in the presence of a decrease in the activity of serotoninergic processes, that was achieved by parachloramphetamine administration in doses of 5 and 15 mg/kg. It is concluded that the activating effect of diazepam is not mediated through the serotoninergic systems of the brain.