大鼠松果体中昼夜节律的光诱导、药理学及相位移动

Photoentrainment, pharmacology, and phase shifts of the circadian rhythm in the rat pineal.

作者信息

Zatz M

出版信息

Fed Proc. 1979 Nov;38(12):2596-601.

Abstract

Photoentrainment of circadian rhythms in mammals is mediated by the retinohypothalamic projection to the suprachiasmatic nucleus of the hypothalamus. It should therefore be possible to mimic or block the effects of light on the circadian pacemaker with appropriate pharmacological agents. Such agents and their effects should be useful in identifying the neurotransmitters involved in photoentrainment and their mechanisms of action on the circadian pacemaker. The effects of light on the circadian rhythm in rat pineal serotonin N-acetyltransferase activity are described. Carbachol, a cholinergic agonist, was found to mimic the effects of light on this rhythm, including the acute reduction of nocturnal activity and phase-shifting of the free-running rhythm. These results raise the possibility that acetylcholine is involved in the photoentrainment of mammalian circadian rhythms.

摘要

哺乳动物昼夜节律的光调节是由视网膜下丘脑投射到下丘脑视交叉上核介导的。因此，应该有可能用合适的药物模拟或阻断光对昼夜节律起搏器的影响。这类药物及其作用在确定参与光调节的神经递质及其对昼夜节律起搏器的作用机制方面应该是有用的。本文描述了光对大鼠松果体血清素N-乙酰转移酶活性昼夜节律的影响。发现胆碱能激动剂卡巴胆碱可模拟光对该节律的影响，包括夜间活动的急性减少和自由运行节律的相位改变。这些结果增加了乙酰胆碱参与哺乳动物昼夜节律光调节的可能性。