脑室内注射卡巴胆碱可模拟光对昼夜节律性轮转运动活动的相位转移效应。
Intraventricular carbachol mimics the phase-shifting effect of light on the circadian rhythm of wheel-running activity.
作者信息
Zatz M, Herkenham M A
出版信息
Brain Res. 1981 May 11;212(1):234-8. doi: 10.1016/0006-8993(81)90059-7.
PMID:7225860
Abstract
Intraventricular injections of carbachol, a cholinergic agonist, into free-running mice can cause phase dependent phase shifts, in both directions, in the circadian rhythm of wheel-running activity. These effects mimic the action of light in entraining the circadian pacemaker, and suggest that acetylcholine may play a role in photoentrainment.
摘要
向自由活动的小鼠脑室内注射胆碱能激动剂卡巴胆碱，可导致其昼夜节律的轮跑活动出现相位依赖性的相位变化，变化方向有两种。这些效应模拟了光对昼夜节律起搏器的调节作用，表明乙酰胆碱可能在光调节昼夜节律中发挥作用。
Zotero 插件