抗利尿激素（ADH）在实验性高血压大鼠血压维持中的升压作用（作者译）

[The vasopressor role of ADH in the maintenance of blood pressure in experimentally hypertensive rats (author's transl)].

作者信息

Yajima Y, Sato K, Saito T

出版信息

Nihon Naibunpi Gakkai Zasshi. 1979 Sep 20;55(9):1065-75. doi: 10.1507/endocrine1927.55.9_1065.

DOI:10.1507/endocrine1927.55.9_1065

Abstract

In order to investigate the vasopressor role of ADH in the regulation of blood pressure, passive immunization experiments with an antibody to AVP were carried out in experimentally hypertensive rats. In hypertensive rats treated with deoxycorticosterone acetate (DOCA), spontaneously hypertensive rats (SHR) and spontaneously hypertensive stroke-prone rats (SHR-sp), the intravenous injection of a specific vasopressin antibody resulted in a transient fall of blood pressure of 11 approximately 25mmHg, while in rats with two-kidney Goldblatt hypertension and normal rats, the blood pressure was not affected. This strongly suggests that ADH contributed to systemic vaso-constriction in DOCA hypertension and spontaneous hypertension in rats.

摘要

为了研究抗利尿激素（ADH）在血压调节中的升压作用，在实验性高血压大鼠中进行了用抗精氨酸加压素（AVP）抗体的被动免疫实验。在接受醋酸脱氧皮质酮（DOCA）治疗的高血压大鼠、自发性高血压大鼠（SHR）和自发性高血压易中风大鼠（SHR-sp）中，静脉注射特异性加压素抗体导致血压短暂下降约11至25mmHg，而在二肾型Goldblatt高血压大鼠和正常大鼠中，血压未受影响。这有力地表明，ADH在DOCA高血压和大鼠自发性高血压中促成了全身血管收缩。