Tse K S, Arbesman C E, Tomasi T B, Tourville D
Clin Exp Immunol. 1971 Jun;8(6):881-7.
IgG, IgA and IgM antibodies reacting with myelin sheaths were found in the sera but not in the cerebrospinal fluid of four out of six patients with Guillain-Barré syndrome. These antibodies had organ specificity for myelin of the central and peripheral nervous systems but did not demonstrate species specificity. Similar antibodies, but in much lower titres, were found infrequently in the sera of patients with liver disease and rarely in normal individuals. The organ specificity and the close correlation between antibody titres and disease activity suggest the possibility that these antibodies may play a role in the pathogenesis of Guillain-Barré syndrome. The detection of antimyelin antibodies by immunofluorescence may provide a relatively simple ancillary laboratory aid in the diagnosis of the neurological entity.
在6例格林-巴利综合征患者中，有4例患者的血清中发现了与髓鞘反应的IgG、IgA和IgM抗体，但脑脊液中未发现。这些抗体对中枢和外周神经系统的髓鞘具有器官特异性，但不具有种属特异性。在肝病患者的血清中偶尔也发现类似的抗体，但滴度要低得多，在正常个体中则很少见。抗体的器官特异性以及抗体滴度与疾病活动之间的密切相关性表明，这些抗体可能在格林-巴利综合征的发病机制中起作用。通过免疫荧光检测抗髓鞘抗体可能为该神经疾病的诊断提供一种相对简单的辅助实验室手段。
