Hogan B, Gross P R
J Cell Biol. 1971 Jun;49(3):692-701. doi: 10.1083/jcb.49.3.692.
Emetine is a potent inhibitor of protein synthesis in sea urchin embryos. At a concentration of the drug that rapidly inhibits protein synthesis in blastulae by 95%, uridine incorporation into RNA continues for more than 1 hr and presumptive histone messenger RNA is synthesized and transported into the cytoplasm where it is apparently associated with polyribosomes. Possible explanations of this result and its implications for the "informasome" theory of messenger transport in embryonic cells are discussed.
依米丁是海胆胚胎中蛋白质合成的有效抑制剂。在该药物浓度下,囊胚中的蛋白质合成迅速被抑制95%,但尿苷掺入RNA的过程仍持续超过1小时,推测的组蛋白信使RNA被合成并转运到细胞质中,在那里它显然与多核糖体相关联。本文讨论了这一结果的可能解释及其对胚胎细胞中信使运输“信息体”理论的意义。