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宋内志贺菌15型蛋白质的抗原性、抗生素及噬菌体受体活性

Antigenic, antibiotic and phage receptor activity of proteins from Sh. boydii 15.

作者信息

Goldhar J, Eylan E, Barber C

出版信息

Zentralbl Bakteriol Orig A. 1975;230(3):336-42.

PMID:49990
Abstract

The analyzed strain of Sh. boydii 15 induced antibodies against the somatic antigen conjugate, as in most Shigella. Except for the proteinic carrier of the somatic antigen, only a few of the homologous proteinic determinants induced corresponding antibodies; these were illustrated with the help of a serum to proteins from Sh. sonnei. The proteins of Sh. boydii 15 displayed a wide range of antibiotic activity against Shigella, E. coli and Salmonella. Another aspect concerning the biological activities of the proteins isolated from Sh. boydii 15 was its temperate phage receptor activity. This activity was found as well in the free proteins as in the proteinic moiety of the somatic antigen.

摘要

与大多数志贺氏菌一样,所分析的鲍氏志贺氏菌15菌株诱导产生了针对菌体抗原偶联物的抗体。除了菌体抗原的蛋白质载体外,只有少数同源蛋白质决定簇诱导产生了相应抗体;这些是借助针对宋内志贺氏菌蛋白质的血清进行说明的。鲍氏志贺氏菌15的蛋白质对志贺氏菌、大肠杆菌和沙门氏菌表现出广泛的抗菌活性。从鲍氏志贺氏菌15分离出的蛋白质的生物活性的另一个方面是其温和噬菌体受体活性。在游离蛋白质以及菌体抗原的蛋白质部分中都发现了这种活性。

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