Feldman J M, Blalock J A, Zern R T
Horm Res. 1979;11(4):170-8. doi: 10.1159/000179052.
There is evidence that hypothalamic norepinephrine (NE) plays a role in the control of appetite in the rat. Using specific and sensitive radioenzymatic assays, we determined if there was a difference in the tissue (hypothalamus, cerebral cortex and kidney) concentration of NE or of dopamine (DA) in mice with the hereditary obese-hyperglycemic syndrome (ob/ob) and their normal weight littermates, both when they were in the rapid growth phase (2--3 months of age) and when they were mature (6--7 months of age). The concentration of NE was similar in the cerebral cortex of obese and normal mice and in the kidneys of obese and normal mice. The concentration of DA was similar in the hypothalamus of obese and normal mice. The concentration of DA was similar in the hypothalamus of obese and normal mice and in the cerebral cortex of obese and normal mice. These observations support the concept that alterations in hypothalamic NE may play a role in the obesity of ob/ob mice.
有证据表明，下丘脑去甲肾上腺素（NE）在大鼠的食欲控制中起作用。我们使用特异性和灵敏的放射酶分析法，测定遗传性肥胖-高血糖综合征（ob/ob）小鼠及其正常体重同窝小鼠在快速生长阶段（2至3个月龄）和成熟阶段（6至7个月龄）时，其组织（下丘脑、大脑皮层和肾脏）中NE或多巴胺（DA）的浓度是否存在差异。肥胖小鼠和正常小鼠大脑皮层以及肥胖小鼠和正常小鼠肾脏中的NE浓度相似。肥胖小鼠和正常小鼠下丘脑以及肥胖小鼠和正常小鼠大脑皮层中的DA浓度相似。这些观察结果支持了下丘脑NE的改变可能在ob/ob小鼠肥胖中起作用这一概念。
