Knight L A, Gardner H A, Gallie B L
Hum Genet. 1979 Sep 2;51(1):73-8. doi: 10.1007/BF00278295.
Mixed lymphocyte cultures were employed to assess the degree of spontaneous chromosome fragility in patients with retinoblastoma. There was no difference between the patients and their controls. If chromosome instability plays a role in the inherited tumour, more sensitive methods need be employed to elucidate it.
采用混合淋巴细胞培养来评估视网膜母细胞瘤患者自发染色体脆性程度。患者与其对照组之间无差异。如果染色体不稳定性在遗传性肿瘤中起作用，则需要采用更敏感的方法来阐明这一点。
