遗传性或散发性视网膜母细胞瘤患者二倍体成纤维细胞的X射线敏感性
X-ray sensitivity of diploid fibroblasts from patients with hereditary or sporadic retinoblastoma.
作者信息
Weichselbaum R R, Nove J, Little J B
出版信息
Proc Natl Acad Sci U S A. 1978 Aug;75(8):3962-4. doi: 10.1073/pnas.75.8.3962.
Abstract
Fibroblasts derived from patients with hereditary retinoblastoma appear to be more sensitive to the lethal effects of x-rays than do fibroblasts from patients with sporadic retinoblastoma or normal controls. A defect in DNA repair is postulated to account for the high incidence of second tumors in these patients. Retinoblastoma appears to be an interesting model for the study of genetic susceptibility to the development of spontaneous or radiation-induced tumors.
摘要
与散发性视网膜母细胞瘤患者或正常对照者的成纤维细胞相比，遗传性视网膜母细胞瘤患者的成纤维细胞似乎对X射线的致死效应更敏感。据推测，DNA修复缺陷是这些患者继发性肿瘤高发的原因。视网膜母细胞瘤似乎是研究自发或辐射诱导肿瘤发生的遗传易感性的一个有趣模型。
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3
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