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遗传性或散发性视网膜母细胞瘤患者二倍体成纤维细胞的X射线敏感性

X-ray sensitivity of diploid fibroblasts from patients with hereditary or sporadic retinoblastoma.

作者信息

Weichselbaum R R, Nove J, Little J B

出版信息

Proc Natl Acad Sci U S A. 1978 Aug;75(8):3962-4. doi: 10.1073/pnas.75.8.3962.

DOI:10.1073/pnas.75.8.3962
PMID:279012
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC392909/
Abstract

Fibroblasts derived from patients with hereditary retinoblastoma appear to be more sensitive to the lethal effects of x-rays than do fibroblasts from patients with sporadic retinoblastoma or normal controls. A defect in DNA repair is postulated to account for the high incidence of second tumors in these patients. Retinoblastoma appears to be an interesting model for the study of genetic susceptibility to the development of spontaneous or radiation-induced tumors.

摘要

与散发性视网膜母细胞瘤患者或正常对照者的成纤维细胞相比，遗传性视网膜母细胞瘤患者的成纤维细胞似乎对X射线的致死效应更敏感。据推测，DNA修复缺陷是这些患者继发性肿瘤高发的原因。视网膜母细胞瘤似乎是研究自发或辐射诱导肿瘤发生的遗传易感性的一个有趣模型。

相似文献

1
X-ray sensitivity of diploid fibroblasts from patients with hereditary or sporadic retinoblastoma.遗传性或散发性视网膜母细胞瘤患者二倍体成纤维细胞的X射线敏感性
Proc Natl Acad Sci U S A. 1978 Aug;75(8):3962-4. doi: 10.1073/pnas.75.8.3962.
2
An in vitro investigation of genetic susceptibility to cancer in diploid fibroblasts from retinoblastoma patients.视网膜母细胞瘤患者二倍体成纤维细胞癌症遗传易感性的体外研究。
Teratog Carcinog Mutagen. 1980;1(2):171-9. doi: 10.1002/tcm.1770010206.
3
An in vitro investigation of x-ray sensitivity in fibroblasts from patients with retinoblastoma.视网膜母细胞瘤患者成纤维细胞X线敏感性的体外研究
Invest Ophthalmol Vis Sci. 1983 Jul;24(7):958-61.
4
Repair of potentially lethal X-ray damage in fibroblasts derived from patients with hereditary and D-deletion retinoblastoma.遗传性和D型缺失视网膜母细胞瘤患者来源的成纤维细胞中潜在致死性X射线损伤的修复
Int J Radiat Biol Relat Stud Phys Chem Med. 1985 Apr;47(4):445-56.
5
Unexpected sensitivity to radiation of fibroblasts from unaffected parents of children with hereditary retinoblastoma.患有遗传性视网膜母细胞瘤儿童的未受影响父母的成纤维细胞对辐射的意外敏感性。
Int J Cancer. 2002 Jun 10;99(5):764-8. doi: 10.1002/ijc.10401.
6
Radiation sensitivity of fibroblasts of bilateral retinoblastoma patients as determined by micronucleus induction in vitro.通过体外微核诱导测定双侧视网膜母细胞瘤患者成纤维细胞的辐射敏感性。
Mutat Res. 1985 Oct;152(1):31-8. doi: 10.1016/0027-5107(85)90043-0.
7
Comparison of kinetics of X-ray-induced cell killing in normal, ataxia telangiectasia and hereditary retinoblastoma fibroblasts.正常、共济失调毛细血管扩张症和遗传性视网膜母细胞瘤成纤维细胞中X射线诱导细胞杀伤动力学的比较。
Mutat Res. 1983 May;109(2):297-308. doi: 10.1016/0027-5107(83)90054-4.
8
In vitro sensitivity of normal and hereditary retinoblastoma fibroblasts to DNA-damaging agents.正常及遗传性视网膜母细胞瘤成纤维细胞对DNA损伤剂的体外敏感性
Cancer Res. 1986 Dec;46(12 Pt 1):6305-10.
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X-radiation-induced chromosome breakage in retinoblastoma lymphocytes.视网膜母细胞瘤淋巴细胞中X射线诱导的染色体断裂
Mutat Res. 1987 Jun;178(2):225-33. doi: 10.1016/0027-5107(87)90273-9.
10
Repair and replication of DNA in hereditary (bilateral) retinoblastoma cells after X-irradiation.遗传性（双侧）视网膜母细胞瘤细胞经X射线照射后DNA的修复与复制
Cancer Res. 1982 Apr;42(4):1343-7.

引用本文的文献

1
Human cells compromised for p53 function exhibit defective global and transcription-coupled nucleotide excision repair, whereas cells compromised for pRb function are defective only in global repair.p53功能受损的人类细胞在整体核苷酸切除修复和转录偶联核苷酸切除修复方面存在缺陷，而pRb功能受损的细胞仅在整体修复方面存在缺陷。
Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):15038-43. doi: 10.1073/pnas.96.26.15038.
2
Excess of cancer deaths in grandparents of patients with retinoblastoma.视网膜母细胞瘤患者祖父母中癌症死亡人数过多。
J Med Genet. 1980 Apr;17(2):95-101. doi: 10.1136/jmg.17.2.95.
3
Cultured diploid fibroblasts from patients with the nevoid basal cell carcinoma syndrome are hypersensitive to killing by ionizing radiation.来自痣样基底细胞癌综合征患者的培养二倍体成纤维细胞对电离辐射杀伤高度敏感。
Am J Pathol. 1983 Apr;111(1):50-5.
4
Cell-culture studies on neurofibromatosis (von Recklinghausen's disease). III. Experiments on X-ray sensitivity.神经纤维瘤病（冯·雷克林豪森病）的细胞培养研究。III. X射线敏感性实验。
Arch Dermatol Res. 1985;277(6):439-43. doi: 10.1007/BF00510059.
5
Fibroblast radiosensitivity and intraocular fibrovascular proliferation following radiotherapy for bilateral retinoblastoma.双侧视网膜母细胞瘤放疗后成纤维细胞放射敏感性与眼内纤维血管增生
Br J Ophthalmol. 1986 May;70(5):336-42. doi: 10.1136/bjo.70.5.336.
6
Absence of chromosome breakage in patients with retinoblastoma.视网膜母细胞瘤患者不存在染色体断裂情况。
Hum Genet. 1979 Sep 2;51(1):73-8. doi: 10.1007/BF00278295.

本文引用的文献

1
Retinoblastoma: epidemiologic characteristics.视网膜母细胞瘤：流行病学特征
N Engl J Med. 1971 Aug 5;285(6):307-11. doi: 10.1056/NEJM197108052850602.
2
Mutation and cancer: statistical study of retinoblastoma.突变与癌症：视网膜母细胞瘤的统计学研究
Proc Natl Acad Sci U S A. 1971 Apr;68(4):820-3. doi: 10.1073/pnas.68.4.820.
3
D-group deletion syndromes and retinoblastoma.D组缺失综合征与视网膜母细胞瘤
Am J Ophthalmol. 1974 Jan;77(1):40-5. doi: 10.1016/0002-9394(74)90602-3.
4
Pleiotropic effects of the gene for retinoblastoma.视网膜母细胞瘤基因的多效性作用。
J Med Genet. 1974 Sep;11(3):244-6. doi: 10.1136/jmg.11.3.244.
5
Retinoblastoma and chromosome abnormality. Partial deletion of the long arm of chromosome 13.视网膜母细胞瘤与染色体异常。13号染色体长臂部分缺失。
Arch Ophthalmol. 1974 Dec;92(6):490-3. doi: 10.1001/archopht.1974.01010010504007.
6
Inherent cellular radiosensitivity of human tumors of varying clinical curability.不同临床可治愈性的人类肿瘤的固有细胞放射敏感性。
AJR Am J Roentgenol. 1976 Dec;127(6):1027-32. doi: 10.2214/ajr.127.6.1027.
7
Mutation and childhood cancer: a probabilistic model for the incidence of retinoblastoma.突变与儿童癌症：视网膜母细胞瘤发病率的概率模型
Proc Natl Acad Sci U S A. 1975 Dec;72(12):5116-20. doi: 10.1073/pnas.72.12.5116.
8
Sporadic bilateral retinoblastoma and 13q- chromosomal deletion.散发性双侧视网膜母细胞瘤与13号染色体长臂缺失
Med Pediatr Oncol. 1976;2(4):379-85. doi: 10.1002/mpo.2950020404.
9
Mutation theory of carcinogenesis in retinoblastoma.视网膜母细胞瘤致癌的突变理论。
J Natl Cancer Inst. 1976 Aug;57(2):269-76. doi: 10.1093/jnci/57.2.269.
10
In vitro radiosensitivity of human dipliod fibroblasts derived from patients with unusual clinical responses to radiation.源自对辐射有异常临床反应患者的人二倍体成纤维细胞的体外放射敏感性。
Radiology. 1976 Nov;121(2):479-82. doi: 10.1148/121.2.479.