脑室内注射诱导的吗啡耐受性和依赖性。
Morphine tolerance and dependence induced by intraventricular injection.
作者信息
Eidelberg E, Barstow C A
出版信息
Science. 1971 Oct 1;174(4004):74-6. doi: 10.1126/science.174.4004.74.
PMID:5001035
Abstract
Injection of small quantities of morphine into the cerebral ventricular system of awake, relatively unrestrained, monkeys depressed or abolished operant food-reinforced lever pressing. After repeated injections progressively higher doses of morphine were needed to depress responding. Also, dependence could be demonstrated in these animals by precipitating specific abstinence signs with an antagonist.
摘要
向清醒、相对不受约束的猴子的脑室系统注射少量吗啡，会抑制或消除操作性食物强化的杠杆按压行为。多次注射后，需要逐渐增加吗啡剂量才能抑制反应。此外，通过用拮抗剂引发特定的戒断症状，可以证明这些动物产生了依赖性。
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