4,4,10β-三甲基-反式十氢萘-3β-醇对中国仓鼠卵巢细胞胆固醇生物合成的抑制作用。一种特异性的2,3-氧化角鲨烯环化酶抑制剂。 - Suppr

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超能文献

Inhibition of cholesterol biosynthesis in Chinese hamster ovary cells by 4,4,10 beta-trimethyl-trans-decal-3 beta-ol. A specific 2,3-oxidosqualene cyclase inhibitor.

作者信息

Chang T Y, Schiavoni E S, McCrae K R, Nelson J A, Spencer T A

出版信息

J Biol Chem. 1979 Nov 25;254(22):11258-63.

PMID:500643

Abstract

摘要

相似文献

Inhibition of cholesterol biosynthesis in Chinese hamster ovary cells by 4,4,10 beta-trimethyl-trans-decal-3 beta-ol. A specific 2,3-oxidosqualene cyclase inhibitor.4,4,10β-三甲基-反式十氢萘-3β-醇对中国仓鼠卵巢细胞胆固醇生物合成的抑制作用。一种特异性的2,3-氧化角鲨烯环化酶抑制剂。

J Biol Chem. 1979 Nov 25;254(22):11258-63.

Effects of a 2,3-oxidosqualene-lanosterol cyclase inhibitor 2,3:22,23-dioxidosqualene and 24,25-epoxycholesterol on the regulation of cholesterol biosynthesis in human hepatoma cell line HepG2.2,3-氧化角鲨烯-羊毛甾醇环化酶抑制剂2,3:22,23-二氧化角鲨烯和24,25-环氧胆固醇对人肝癌细胞系HepG2胆固醇生物合成调节的影响

Biochem Pharmacol. 1994 Jul 5;48(1):49-57. doi: 10.1016/0006-2952(94)90222-4.

Potent inhibition of cholesterol biosynthesis in 3T3 fibroblasts by N-[(1,5,9)-trimethyldecyl]-4 alpha,10-dimethyl-8-aza-trans-decal-3 beta-ol, a new 2,3-oxidosqualene cyclase inhibitor.

Biochem Pharmacol. 1988 May 15;37(10):1955-64. doi: 10.1016/0006-2952(88)90542-4.

Effects of a novel 2,3-oxidosqualene cyclase inhibitor on the regulation of cholesterol biosynthesis in HepG2 cells.一种新型2,3-氧化角鲨烯环化酶抑制剂对HepG2细胞中胆固醇生物合成调控的影响。

J Lipid Res. 1996 Jan;37(1):148-58.

N-[(1,5,9)-trimethyl-decyl]-4 alpha,10-dimethyl-8-aza-trans-decal-3 beta-ol a novel potent inhibitor of 2,3-oxidosqualene cycloartenol and lanosterol cyclases.N-[(1,5,9)-三甲基癸基]-4α,10-二甲基-8-氮杂反式十氢萘-3β-醇，一种新型强效的2,3-氧化角鲨烯环阿屯醇合酶和羊毛甾醇环化酶抑制剂。

Biochem Biophys Res Commun. 1986 Jul 31;138(2):764-70. doi: 10.1016/s0006-291x(86)80562-9.

In vitro inhibition of animal and higher plants 2,3-oxidosqualene-sterol cyclases by 2-aza-2,3-dihydrosqualene and derivatives, and by other ammonium-containing molecules.2-氮杂-2,3-二氢角鲨烯及其衍生物以及其他含铵分子对动物和高等植物2,3-氧化角鲨烯-甾醇环化酶的体外抑制作用。

Biochem Pharmacol. 1985 Aug 1;34(15):2765-77. doi: 10.1016/0006-2952(85)90578-7.

Ro 48-8.071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys, and minipigs: comparison to simvastatin.Ro 48 - 8.071，一种新型的2,3-氧化角鲨烯：羊毛甾醇环化酶抑制剂，可降低仓鼠、松鼠猴和小型猪的血浆胆固醇：与辛伐他汀的比较。

J Lipid Res. 1997 Feb;38(2):373-90.

An alternative mechanism for the inhibition of cholesterol biosynthesis in HepG2 cells by N-[(1,5,9)-trimethyldecyl]-4 alpha,10-dimethyl-8-aza-trans-decal-3 beta-ol (MDL 28,815).

J Pharmacol Exp Ther. 1993 Dec;267(3):1243-9.

Effects of a novel 2,3-oxidosqualene cyclase inhibitor on cholesterol biosynthesis and lipid metabolism in vivo.一种新型2,3-氧化角鲨烯环化酶抑制剂对体内胆固醇生物合成和脂质代谢的影响。

J Lipid Res. 1997 Mar;38(3):564-75.

Topographic heterogeneity in cholesterol biosynthesis.胆固醇生物合成中的地形异质性。

J Biol Chem. 1988 Jul 5;263(19):9366-73.

引用本文的文献

3-Hydroxy-3-methylglutaryl CoA reductase inhibitors up-regulate transforming growth factor-beta signaling in cultured heart cells via inhibition of geranylgeranylation of RhoA GTPase.3-羟基-3-甲基戊二酰辅酶A还原酶抑制剂通过抑制RhoA GTP酶的香叶基香叶基化作用，上调培养的心脏细胞中的转化生长因子-β信号传导。

Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11525-30. doi: 10.1073/pnas.96.20.11525.

Induction of the cholesterol metabolic pathway regulates the farnesylation of RAS in embryonic chick heart cells: a new role for ras in regulating the expression of muscarinic receptors and G proteins.胆固醇代谢途径的诱导调节胚胎鸡心脏细胞中RAS的法尼基化：RAS在调节毒蕈碱受体和G蛋白表达中的新作用。

EMBO J. 1997 Dec 15;16(24):7250-60. doi: 10.1093/emboj/16.24.7250.

Changes in sterol biosynthesis accompanying cessation of glial cell growth in serum-free medium.无血清培养基中神经胶质细胞生长停止时甾醇生物合成的变化。

Biochem J. 1980 Nov 15;192(2):709-17. doi: 10.1042/bj1920709.

Effects of unsaturated fatty acid deprivation on neutral lipid synthesis in Saccharomyces cerevisiae.不饱和脂肪酸剥夺对酿酒酵母中性脂质合成的影响。

J Bacteriol. 1982 Nov;152(2):747-56. doi: 10.1128/jb.152.2.747-756.1982.

Oxysterols: chemical synthesis, biosynthesis and biological activities.氧化甾醇：化学合成、生物合成及生物活性

Lipids. 1986 Jan;21(1):27-30. doi: 10.1007/BF02534299.

The squalene-2,3-epoxide cyclase as a model for the development of new drugs.角鲨烯-2,3-环氧化酶作为新型药物开发的模型。

Lipids. 1986 Jan;21(1):31-8. doi: 10.1007/BF02534300.

Inhibition by the fungicide fenpropimorph of cholesterol biosynthesis in 3T3 fibroblasts.杀菌剂粉唑醇对3T3成纤维细胞中胆固醇生物合成的抑制作用。

Biochem J. 1988 Dec 15;256(3):829-34. doi: 10.1042/bj2560829.

Calmodulin antagonists suppress cholesterol synthesis by inhibiting sterol delta 24 reductase.钙调蛋白拮抗剂通过抑制甾醇Δ24还原酶来抑制胆固醇合成。

Lipids. 1987 Apr;22(4):261-5. doi: 10.1007/BF02533989.

Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in human hepatoma cell line Hep G2. Effects of inhibitors of cholesterol synthesis on enzyme activity.人肝癌细胞系Hep G2中3-羟基-3-甲基戊二酰辅酶A还原酶的调节。胆固醇合成抑制剂对酶活性的影响。

Biochem J. 1987 Jan 15;241(2):345-51. doi: 10.1042/bj2410345.

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