大鼠粪便细菌对3α,7α,12α-三羟基-5β-胆甾烷-26-酸牛磺酸结合物的裂解作用。
Cleavage of the taurine conjugate of 3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholestan-26-oic acid by rat fecal bacteria.
作者信息
Batta A K, Salen G, Cheng F W, Shefer S
出版信息
J Biol Chem. 1979 Dec 10;254(23):11907-9.
This paper describes a method for the hydrolysis of the taurine conjugates of the 25R and the 25S diastereoisomers of 3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholestan-26-oic acid (THCA) with retention of original configuration of C-25. Rat fecal suspensions were incubated with the taurine conjugate of THCA for 5 and 60% of the free THCA was recovered. When bile from Alligator mississippiensis, which contains mostly the taurine conjugate of THCA, was analyzed by this method, THCA was obtained with the 25R configuration.
本文描述了一种水解3α,7α,12α-三羟基-5β-胆甾烷-26-酸（THCA）的25R和25S非对映异构体的牛磺酸结合物的方法，同时保留C-25的原始构型。将大鼠粪便悬浮液与THCA的牛磺酸结合物一起孵育，回收了5%和60%的游离THCA。当用这种方法分析主要含有THCA牛磺酸结合物的密西西比短吻鳄胆汁时，得到了具有25R构型的THCA。
Zotero 插件