大鼠和人肝脏微粒体环氧化物水解酶。纯化及多种形式存在的证据。 - Suppr

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Rat and human liver microsomal epoxide hydratase. Purification and evidence for the existence of multiple forms.

作者信息

Guengerich F P, Wang P, Mitchell M B, Mason P S

出版信息

J Biol Chem. 1979 Dec 10;254(23):12248-54.

PMID:500710

Abstract

摘要

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Rat and human liver microsomal epoxide hydratase. Purification and evidence for the existence of multiple forms.大鼠和人肝脏微粒体环氧化物水解酶。纯化及多种形式存在的证据。

J Biol Chem. 1979 Dec 10;254(23):12248-54.

Separation and purification of multiple forms of microsomal cytochrome P-450. Partial characterization of three apparently homogeneous cytochromes P-450 prepared from livers of phenobarbital- and 3-methylcholanthrene-treated rats.

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Purification of cytochrome P-450, NADPH-cytochrome P-450 reductase, and epoxide hydratase from a single preparation of rat liver microsomes.从大鼠肝脏微粒体的单一制剂中纯化细胞色素P-450、NADPH-细胞色素P-450还原酶和环氧化物水合酶。

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Effects of phenobarbital, trans-stilbene oxide, and 3-methylcholanthrene on epoxide hydrolase within centrilobular, midzonal, and periportal regions of rat liver.苯巴比妥、反式氧化茋和3-甲基胆蒽对大鼠肝小叶中心、中间和汇管区环氧水解酶的影响。

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Benzo(a)pyrene-4,5-oxide hydratase: assay, properties, and induction.苯并(a)芘-4,5-氧化物水合酶：测定、性质及诱导作用

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Sex and age dependence of the "selective" induction of rat hepatic microsomal epoxide hydratase following trans-stilbene oxide, l-alpha-acetylmethadol, or phenobarbital treatment.反式氧化茋、左旋 - α - 乙酰美沙朵或苯巴比妥处理后大鼠肝微粒体环氧化物水解酶“选择性”诱导的性别和年龄依赖性。

Biochem Pharmacol. 1980 Dec;29(24):3245-51. doi: 10.1016/0006-2952(80)90298-1.

Regulation of rat liver epoxide hydratase activity by phenobarbital and 3-methylcholanthrene.苯巴比妥和3-甲基胆蒽对大鼠肝脏环氧化物水解酶活性的调节

Biochem Pharmacol. 1979 Jul 15;28(14):2175-9. doi: 10.1016/0006-2952(79)90200-4.

Hydrophobic chromatography: a one-step method for the purification of human liver microsomal epoxide hydrolase.疏水色谱法：一种纯化人肝微粒体环氧化物水解酶的一步法

J Chromatogr. 1988 Apr 8;426(1):169-76. doi: 10.1016/s0378-4347(00)81939-8.

Human hepatic microsomal epoxide hydrolase. A structural comparison with the rat enzyme.人肝微粒体环氧化物水解酶。与大鼠酶的结构比较。

J Biol Chem. 1982 Mar 10;257(5):2708-12.

Purification and characterization of the major microsomal cytochrome P-450 form induced by trans-stilbene oxide in rat liver.反式氧化茋诱导的大鼠肝脏主要微粒体细胞色素P-450形式的纯化与表征

Biochim Biophys Acta. 1984 Aug 28;789(1):1-9. doi: 10.1016/0167-4838(84)90053-0.

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Effect of phenobarbital on the level of translatable rat liver epoxide hydrolase mRNA.苯巴比妥对大鼠肝脏可翻译的环氧化物水解酶mRNA水平的影响。

Proc Natl Acad Sci U S A. 1981 Feb;78(2):893-7. doi: 10.1073/pnas.78.2.893.

Assessment of the drug metabolism capacity of the liver.肝脏药物代谢能力的评估。

Br J Clin Pharmacol. 1982 Nov;14(5):631-51. doi: 10.1111/j.1365-2125.1982.tb04950.x.

Valpromide inhibits human epoxide hydrolase.丙戊酰胺抑制人环氧水解酶。

Br J Clin Pharmacol. 1986 Sep;22(3):269-74. doi: 10.1111/j.1365-2125.1986.tb02886.x.

Microsomal epoxide hydrolase of rat liver. Purification and characterization of enzyme fractions with different chromatographic characteristics.大鼠肝脏微粒体环氧化物水解酶。具有不同色谱特性的酶组分的纯化与表征。

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