Sanerkin N G, Gallagher P
J Bone Joint Surg Br. 1979 Nov;61-B(4):395-400. doi: 10.1302/0301-620X.61B4.500746.
Sixty-two cases of chondrosarcoma of bone were reviewed and histologically graded as low, medium or high-grade tumours. After excluding patients dead from unrelated causes or lost to follow-up, forty cases were available for ten-year follow-up and fifty-eight for five-year follow-up. The rates of survival, recurrence and metastasis were analysed according to the histological grading. Recurrence was further analysed according to the adequacy of treatment. The results were compared with those previously reported in the literature. There was a ten-year survival rate of 58 per cent. Recurrence developed in 58 per cent and was uncontrollable in 29 per cent. The recurrence rate was 87 per cent with inadequate treatment and 15 per cent with adequate treatment. Recurrences outside the limb bones usually proved uncontrollable; recurrences in the limb bones were amenable to further, and if necessary repeated, operations. High-grade chondrosarcoma had a metastatic risk of 75 per cent and eventual mortality of 88 per cent. Medium-grade chondrosarcoma had a metastatic risk of 14 per cent and a mortality of 60 per cent. Low-grade chondrosarcoma had a metastatic risk of 5 per cent and a mortality of 29 per cent.
回顾了62例骨软骨肉瘤病例，并根据组织学将其分级为低级别、中级别或高级别肿瘤。排除因无关原因死亡或失访的患者后，40例患者可进行十年随访，58例可进行五年随访。根据组织学分级分析生存率、复发率和转移率。根据治疗的充分性进一步分析复发情况。将结果与文献中先前报道的结果进行比较。十年生存率为58%。58%的患者出现复发，其中29%的复发无法控制。治疗不充分时复发率为87%，治疗充分时为15%。四肢骨以外部位的复发通常无法控制；四肢骨的复发可通过进一步手术（必要时重复手术）进行治疗。高级别软骨肉瘤的转移风险为75%，最终死亡率为88%。中级别软骨肉瘤的转移风险为14%，死亡率为60%。低级别软骨肉瘤的转移风险为5%，死亡率为29%。
