Tan K L, Chan Y C
Br Med J. 1972 Jan 29;1(5795):269-70. doi: 10.1136/bmj.1.5795.269.
Serum IgM and IgA levels were measured in 97 newborn infants with and 141 without hepatosplenomegaly. All were considered normal at birth and had no apparent disease on clinical examination. Thirty per cent. of the infants with hepatosplenomegaly were found to have IgM levels of 20 mg/100 ml or greater, a level established as abnormal when compared with the control group. The number of infants with raised IgM level and the geometric mean level were significantly different (P < 0.001) from those in the control group. No difference, however, was found in serum IgA levels between the two groups of infants. The results suggest that intrauterine infections may sometimes be the cause of hepatosplenomegaly in newborn infants without apparent disease.
对97例有肝脾肿大和141例无肝脾肿大的新生儿测量了血清IgM和IgA水平。所有新生儿出生时均被视为正常，临床检查无明显疾病。发现30%有肝脾肿大的婴儿IgM水平达到或高于20mg/100ml，与对照组相比，这一水平被确定为异常。IgM水平升高的婴儿数量和几何平均水平与对照组有显著差异（P<0.001）。然而，两组婴儿的血清IgA水平没有差异。结果表明，宫内感染有时可能是无明显疾病的新生儿肝脾肿大的原因。
