Baker J B, Humphreys T
Science. 1972 Feb 25;175(4024):905-6. doi: 10.1126/science.175.4024.905.
In confluent cultures normal chick embryo fibroblasts become highty agglutinable by concanavalin A within 6 hours after their synthesis of protein is inhibited by cycloheximide, pactamycin, or emetine. When growing cells are similarly treated, they fail to become more agglutinable. Apparently, molecules which maintain the normal structure of the cell surface must be replaced continually when cell growth is contact inhibited.
在汇合培养物中，正常鸡胚成纤维细胞在其蛋白质合成被放线菌酮、密旋霉素或吐根碱抑制后6小时内，会变得极易被伴刀豆球蛋白A凝集。当对生长中的细胞进行类似处理时，它们不会变得更易凝集。显然，当细胞生长受到接触抑制时，维持细胞表面正常结构的分子必须不断更新。
