Chabert J M, Soummer A M, Chambon P, Grimaud D, Maestracci P
Ann Anesthesiol Fr. 1975 Mar-Apr;16(2):91-6.
This was shown by the unexpected discovery of the urinary excretion of mannitol when urinary sorbitol levels were being measured in connection with the surveillance of patients suffering from malnutrition and head injury and receiving total parenteral nutrition: glucose, sorbitol, amino-acids, soya oil. The presence of mannitol in the urine would appear to result from a secondary catabolic through physiological pathway for the fructose produced by the metabolism of sortibol not metabolised during glycolysis.
在对患有营养不良和头部损伤且接受全胃肠外营养（葡萄糖、山梨醇、氨基酸、大豆油）的患者进行监测时，测量尿中山梨醇水平时意外发现甘露醇的尿排泄情况，这表明了上述情况。尿液中甘露醇的存在似乎是由于山梨醇代谢产生的果糖在糖酵解过程中未被代谢，通过生理途径进行二次分解代谢所致。
