Katayama Y, Kodama K, Kubo Y
J Nutr Sci Vitaminol (Tokyo). 1979;25(3):229-41. doi: 10.3177/jnsv.25.229.
In liver homogenates of rats fed a low-level diet of Wheat-Rice- or Miyazaki-pattern amino acid mixture, some enzymes such as glucose-6-phosphate dehydrogenase, ATP citrate lyase, fatty acid-synthesizing enzymes, malic enzyme and L-alpha-glycerophosphate dehydrogenase, whose activities are indicators of lipogenesis have been determined from the viewpoint of the mechanisms producing fatty liver. In the early experimental period, malic enzyme activity increased more markedly in rats fed low amino acid mixture diets than in the control group, and L-alpha-glycerophosphate dehydrogenase activity in the liver increased slightly. Conversely, ATP citrate lyase and fatty acid-synthesizing enzyme activities remained almost at control levels, or glucose-6-phosphate dehydrogenase activity tended to decrease. These results suggest that some other associated factors, such as depression of the lipid transfer system in the liver rather than accelerated lipogenesis itself, may be the main cause of the fatty livers produced under these nutritional conditions.
在喂食低水平小麦 - 大米或宫崎模式氨基酸混合物饮食的大鼠肝脏匀浆中，从脂肪肝产生机制的角度测定了一些酶，如葡萄糖 - 6 - 磷酸脱氢酶、ATP柠檬酸裂解酶、脂肪酸合成酶、苹果酸酶和L-α-磷酸甘油脱氢酶，这些酶的活性是脂肪生成的指标。在实验初期，喂食低氨基酸混合物饮食的大鼠中苹果酸酶活性比对照组增加更为明显，肝脏中L-α-磷酸甘油脱氢酶活性略有增加。相反，ATP柠檬酸裂解酶和脂肪酸合成酶活性几乎保持在对照水平，或者葡萄糖 - 6 - 磷酸脱氢酶活性有下降趋势。这些结果表明，在这些营养条件下产生脂肪肝的主要原因可能是肝脏中脂质转运系统的抑制等其他相关因素，而不是脂肪生成本身的加速。
